Using sol-gel processing techniques that incorporate nano-structuring technology, a durable, homogeneous porous shell is grown on a solid silica core to create a core-shell particle. This particle morphology results in less band broadening compared to fully porous particles and thus delivers extremely high efficiencies.
Core-shell Technology Results in Less Band Broadening
The Van Deemter equation describes the three sources of band broadening (A - Eddy diffusion, B - longitudinal diffusion, C - mass transfer).
In order to maximize efficiency, sources of band broadening need to be minimized. With core-shell particles, all three sources (A, B, & C) are reduced compared to fully porous particles as seen in the graphs below*. This reduction in band broadening results in chromatographic separations with better resolution, higher sensitivity, and improved peak capacities.
*Gritti and Guiochon, 2012. LC-GC 30(7) 586-595.
Kinetex Core-shell Technology delivers dramatic improvements in efficiency over fully porous media which can be leveraged to increase resolution, improve productivity, reduce solvent consumption, and decrease costs. Whether you are running HPLC or UHPLC methods, the Kinetex Core-shell family can deliver shockingly improved performance over the current column you are using.
- Kinetex 5 µm – Instantly Improve Fully Porous 5 µm & 3 µm Methods
- Kinetex 2.6 µm – A Versatile Upgrade for HPLC & UHPLC
- Kinetex 1.7 & 1.3 µm – Get the most Performance out of your UHPLC System
||UHPLC & HPLC
||HPLC & PREP LC
|Typical Efficiency (p/m)
|Typical Backpressure (bar)
||< 250 bar
Vs. Fully Porous Particles
The highly optimized process used to manufacture Kinetex core-shell particles combined with industry leading column packing technology produces highly reproducible columns that generate extremely high plate counts compared to fully porous particles. This ultra-high efficiency can be leveraged to achieve increased resolution, improved sensitivity, higher productivity, and significant cost savings on new and existing methods.
- High particle density helps create optimal bed structure which reduces band broadening effects of Eddy Diffusion
- Ultra-high performance on HPLC and UHPLC systems alike
- Reduced diffusion path improves efficiency
- Less homogenuous bed structure leads to performance loss
- Ultra-high performance limited to sub 2-µm particles on UHPLC systems
- Diffusion path limits efficiencies
Extremely High Efficiencies with Core-shell Particle
Unleash the power of Kinetex core-shell technology to achieve results just not possible on conventional fully porous materials. No matter what type of system you have or type of analysis you are performing, there is a Kinetex solution for you.
Kinetex 5 µm - Immediately improve resolution, productivity, and sensitivity of 3 μm and 5 μm fully porous HPLC methods
- Clear efficiency gains over both 5 and 3 µ columns at 5 µm pressure for isocratic methods
- 3 µm or better peak capacities at 5 µm backpressures for gradient methods
- Ultra-high efficiency separation for PREP LC
Higher Resolution with No Pressure Increase
Higher Sensitivity without Pressure Increase
High Efficiency Lab Scale Prep LC Purification
Kinetex 2.6 µm - A flexible solution for increasing resolution, reducing analysis times, and decreasing solvent usage on both HPLC & UHPLC methods
- Potential of UHPLC-equivalent efficiency HPLC systems
- Get more out of UHPLC systems by leveraging low backpressure
Sub-2 µm Performance with Kinetex 2.6 µm on HPLC and UHPLC Systems
Decrease Run Time and Increase Resolution (or Maximize Throughput)
Kinetex 1.3 µm & 1.7 µm - Highest efficiencies available on UHPLC systems for improved resolution of critical pairs and higher sensitivity
Incredible Efficiency Gains
Labs leveraging the ultra-high efficiency of Kinetex core-shell technology can significantly reduce their lab costs by greatly shortening analysis times resulting in reduced solvent usage, increased sample throughput, and improved instrument productivity.
Ultra-high efficiency Kinetex core-shell technology allows run times to be dramatically reduced by manipulating flow rate and column lengths while maintaining excellent chromatographic performance.
Waters and Symmetry are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Waters Corporation. Competitive separation may not be representative of all applications.
Easy Method Transfer
Easily transfer methods developed on Kinetex core-shell columns to ANY LC system, anywhere in the world. Because Kinetex 1.7 µm, 2.6 µm, & 5 µm particles are completely scalable, you can freely move between HPLC, UHPLC, and PREP LC systems. Now, you can develop a method on a standard HPLC system that can easily be transferred to a UHPLC system – and vice versa!
Analytical Scalability and Portability HPLC to UHPLC