Region

Oligonucleotide

Purification Products

Clarity HPLC Information


Purification and Analysis of Synthetic Oligonucleotides

The Clarity BioSolutions LC portfolio includes novel RP-LC and IEX-LC columns for purifying and characterizing synthetic DNA / RNA used in biological research, therapeutic development, and biochemical manufacturing.

 

• Clarity Oligo-SAX: High Capacity Ion-Exchange Analysis and Characterization

 

• Clarity Oligo-XT: High Efficiency LC/MS Analysis Scaling Directly to LC Purification

 

Clarity Oligo-MS™: LC/MS analysis

 

Clarity Oligo-RP™: RP-LC purification and analysis

 

Clarity Oligo-WAX™: IEX-LC purification

 

Oligo-MS


Particle Sizes (µm)1.7, 2.6
Pore Size (Å)100
Compare All Phases

Oligo-MS Phase Information


Clarity Oligo-MS, C18 columns have been engineered for the MS characterization of synthetic DNA and RNA samples.  This media is based on core-shell technology which generates extremely high efficiencies due to the innovative particle design.  This increase in efficiency improves the resolution between critical oligo sequences, gives higher sensitivity for easier MS quantitation, and allows for a decrease in column length for higher throughput.

  • Core-shell particle technology provides improved speed, resolution, and sensitivity
  • 2.6 µm particles deliver increased efficiency at reduced backpressures
  • Easily transfer quantitative LC/MS methods to any system with 2.6 µm particles
  • 1.7 µm particles boost performance of existing sub-2 µm methods
PhaseParticle Sizes (µm)Pore Size (Å)Recommended Use
Oligo-MS1.7, 2.6100Rapid LC/MS analysis and QC of synthetic oligonucleotide research reagents and therapeutics
Oligo-RP3, 5, 10110Purification of synthetic oligonucleotide mixtures
Oligo-SAX5N/A
Oligo-WAX10400Preparative purification of synthetic oligonucleotide mixtures
Oligo-XT1.7, 2.6, 5100
Document Type:
Document Type Title
Brochures Axia PrePacked Preparative HPLC and SFC Brochure Add to My Documents
Technical Notes Analysis of Synthetic Oligonucleotides using Quaternary Amine Functionalized, Non-porous Particles - Clarity Oligo-SAX (TN-1206) Add to My Documents
Technical Notes Automated Method Development of Oligonucleotide in Tissues Using Clarity OTX 96-Well Plate and High Resolution Mass Spectrometry (TN-0097) Add to My Documents
Brochures Clarity LC Solutions Add to My Documents
Brochures Improve Your Bioanalytical Assays Today Add to My Documents
Other Ultimate Guide to Reversed Phase HPLC/UHPLC - Column Selectivity Selection Poster Add to My Documents
Technical Notes Avoiding Depurination During Trityl-on Purification (TN-0008) Add to My Documents
Brochures Bulk Media Selection Guide Add to My Documents
Technical Notes Oligonucleotide Therapeutics from Biological Matrices (TN-0048) Add to My Documents
Technical Notes Optimization of Mobile Phase Composition for the Analysis of Synthetic Oligonucleotides using a Clarity Oligo-XT Column (TN-1200) Add to My Documents
Technical Notes Synthetic Oligonucleotides by LC/MS (TN-1052) Add to My Documents
MSDS Safety Data Sheet for Silica-Based HPLC Columns Add to My Documents
Supporting Docs Allowable Adjustments to Pharmacopoeia Methods Add to My Documents
Supporting Docs Meeting All Your PREP Needs Add to My Documents
Other Protein and Peptide Users Guide Add to My Documents
Supporting Docs HPLC Column Care Guide Add to My Documents
Phase: Particle Size: Pore Size: Length: Internal Diameter:
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Part Number:00B-4480-AN

Description:Clarity® 1.7 µm Oligo-MS 100A, LC Column 50 x 2.1 mm, Ea

Required Holder:

Stationary Phase:C18

Solid Support:Core-shell Silica

Format:Column

Separation Mode:Reversed Phase

Recommended Use:Rapid LC/MS analysis and QC of synthetic oligonucleotide research reagents and therapeutics

USP Designation:L1


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