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Rugged, pH stable HPLC Columns

Gemini HPLC Information


U.S. Patent No. 7, 563, 367

Setting the Standard for pH Method Development

Rugged reversed phase HPLC columns that offer extended lifetime under extreme pH conditions and excellent stability for reproducible, high efficiency separations.

  • Take full advantage of high and low pH conditions (pH 1-12) to manipulate selectivity
  • Expect longer column lifetime with patented TWIN-NX technology
  • Ideal for analytical and preparative separations of basic and acidic compounds

Inside Twin Technology

During the final stage of silica manufacturing a unique silica-organic layer is grafted to create a completely new composite particle. This composite particle particle retains its mechanical strength and rigidity along with excellent efficiency, while the silica-organic shell protects the particle from chemical attack.

Inside Twin-NX Technology

TWIN-NX technology uses an improved patented organo-silica grafting process which incorporates highly stabilizing ethane crosslinking.TWIN-NX technology uses an improved patented organo-silica grafting process which incorporates highly stabilizing ethane crosslinking

Gemini C18 and C6-Phenyl
TWIN Technology

Gemini NX-C18
TWIN-NX Technology

NX-C18


Particle Sizes (µm)3, 5, 10
Pore Size (Å)110
Surface Area (sq. m/g)375
Carbon Load (%)14
Compare All Phases

NX-C18 Phase Information


The most rugged and highly efficient Gemini phase.

  • Control selectivity of ionizable compounds for optimized methods
  • Consistent performance in both volatile and non-volatile buffers
  • High and low pH methods
PhaseParticle Sizes (µm)Pore Size (Å)Surface Area (sq. m/g)Carbon Load (%)Recommended Use
C183, 5, 1011037514Separation of basic compounds under high pH conditions
C6-Phenyl3, 511037512Separation of aromatic, polar, or basic compounds under high pH conditions
NX-C183, 5, 1011037514High efficiency analytical or preparative separations under extreme pH conditions
Document Type:
Document Type Title
Brochures Axia PrePacked Preparative HPLC and SFC Brochure Add to My Documents
Other Clinical Research Solutions Guide Add to My Documents
Brochures Custom Method Development and Optimization Services for Clinical Research Add to My Documents
Brochures Extend your Analytical and Preparative HPLC/ SFC Column Lifetimes Add to My Documents
Technical Notes Glyphosate Analysis by LC/MS/MS using FMOC Derivitization or Underivitized Method Add to My Documents
Technical Notes Hormones from Drinking Water by LC/MS/MS (TN-1163) Add to My Documents
Technical Notes Vitamin C from Tablets and Soft-Gels by HPLC-UV (TN-1153) Add to My Documents
Other HPLC/UHPLC Column Phase Selection Chart Add to My Documents
Technical Notes Impact of pH on the Purity and Yield for Preparative HPLC Separations (TN-1050) Add to My Documents
Technical Notes Basic Compounds by LC/MS using a High pH Mobile Phase (TN-1031) Add to My Documents
Brochures New pH Stable Media for Maximum Lifetime in Preparative Purifications Add to My Documents
Brochures Pain Panel Research and Solutiuons Brochure Add to My Documents
Brochures Pesticide Analysis by GC/LC/Sample Prep Add to My Documents
Brochures pH Flexibility Expands Robustness and Reproducibility Add to My Documents
Other Pharmaceutical Analysis Guide- Formulations Add to My Documents
Technical Notes Low Concentration Amphetamines by SPE and LC/MS/MS (TN-0020) Add to My Documents
Brochures SecurityGuard Column Protection Family Brochure (UHPLC, HPLC, PREP, SFC) Add to My Documents
Other THE Clinical Application Notebook, Volume 1 Add to My Documents
Other Ultimate Guide to Reversed Phase HPLC/UHPLC - Column Selectivity Selection Poster Add to My Documents
Other Vitamin Testing Applications Guide Add to My Documents
Technical Notes Basic Compounds by LC/MS using High pH Mobile Phase (TN-1031) Add to My Documents
Technical Notes A Simple and Effective High pH LC/MS/MS Method for Determination of Underivatized Vitamin B1 and B6 in Human Whole Blood (TN-1205) Add to My Documents
Technical Notes Antibiotics Screen from Bovine Kidney Juice by LC/MS/MS (TN-1117) Add to My Documents
Brochures Axia Packed Gemini-NX Preparative Columns Add to My Documents
Brochures Bulk Media Selection Guide Add to My Documents
Technical Notes Sulfonamides from Honey by LC/MS/MS (TN-0012) Add to My Documents
Technical Notes Steroids from Urine and Plasma by SPE and LC/MS/MS (TN-1026) Add to My Documents
Technical Notes Acetaminophen, Phenylephrine, Chlorpheneramine and Dextromethorphan by HPLC-UV (TN-1044) Add to My Documents
Technical Notes Mycotoxins and Other Fungal/Bacterial Metabolites from Several Food Matrices by LC/MS/MS (TN-1119) Add to My Documents
Technical Notes Nicotine, Cotinine, 3-Hydroxycotinine, Nornicotine and Anabasine in Human Urine by LC/MS/MS (TN-1161) Add to My Documents
Technical Notes Optimization of Wash/Elution Conditions for Automated SPE of Testosterone from Plasma (TN-0017) Add to My Documents
Supporting Docs pH LC Poster Add to My Documents
Brochures Preparative Columns Redefined Add to My Documents
Technical Notes Pyridoxal 5'-phosphate and Pyridoxic Acid in Human Plasma by HPLC-FLD (TN-1159) Add to My Documents
MSDS Safety Data Sheet for Silica-Based HPLC Columns Add to My Documents
Technical Notes Nicotinic Acid and Nicotinamide in Human Plasma by LC/MS/MS (TN-1151) Add to My Documents
Technical Notes Sudan Dye Contaminants in Spices by HPLC/UV (TN-015) Add to My Documents
Technical Notes Thiamine Monophosphate (TMP) and Thiamine from Human Breast Milk (TN-0062) Add to My Documents
Technical Notes Using pH-LC to Control Selectivity of Acidic and Basic Compounds by HPLC (TN-1042) Add to My Documents
Other Vitamin Testing Application Guide Add to My Documents
Supporting Docs Allowable Adjustments to Pharmacopoeia Methods Add to My Documents
Brochures AXIA Preparative Family Brochure Add to My Documents
Technical Notes Impact of pH on Improving Purity and Yield for Preparative Separations (TN-1050) Add to My Documents
Technical Notes Increase Column Performance and Lifetime in Peptide and Protein Purification using Aggressive Wash Conditions (TN-1138) Add to My Documents
Supporting Docs Meeting All Your PREP Needs Add to My Documents
Supporting Docs Meeting All Your SFC Needs Add to My Documents
Technical Notes Peptide Purification Method Development: Application for the Purification of Bivalirudin (TN-1129) Add to My Documents
Technical Notes Using Aromatic Selectivity for Difficult HPLC Separations (TN-1029) Add to My Documents
Supporting Docs Axia Packed Columns Vs Traditional Packed Preparative Columns (Video) Add to My Documents
Supporting Docs HPLC Column Care Guide Add to My Documents
Phase: Particle Size: Pore Size: Length: Internal Diameter:
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Part Number:00D-4454-P0-AX

Description:Gemini® 5 µm NX-C18 110 Å, LC Column 100 x 21.2 mm, AXIA™ Packed, Ea

Required Holder:

Stationary Phase:

Solid Support:Fully Porous Organo-silica

Format:AXIAL Compression

Separation Mode:Reversed Phase

Recommended Use:High efficiency analytical or preparative separations under extreme pH conditions

USP Designation:L1


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