Purification Products

Clarity HPLC Information

Purification and Analysis of Synthetic Oligonucleotides

The Clarity BioSolutions LC portfolio includes novel RP-LC and IEX-LC columns for purifying and characterizing synthetic DNA / RNA used in biological research, therapeutic development, and biochemical manufacturing.


• Clarity Oligo-SAX: High Capacity Ion-Exchange Analysis and Characterization


• Clarity Oligo-XT: High Efficiency LC/MS Analysis Scaling Directly to LC Purification


Clarity Oligo-MS™: LC/MS analysis


Clarity Oligo-RP™: RP-LC purification and analysis


Clarity Oligo-WAX™: IEX-LC purification



Particle Sizes (µm)1.7, 2.6, 5
Pore Size (Å)100
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Oligo-XT Phase Information

Clarity Oligo-XT, C18 columns have been designed to provide rugged high performance for the LC/MS characterization of synthetic DNA and RNA samples, alongside purification of these targeted oligos.  With high efficiency levels from the novel core-shell particle design, this new media provides the necessary separation power to accurately resolve closely related oligo sequences. Additionally, this new technology provides excellent sensitivity levels for easier MS quantitation.

  • Novel core-shell particle technology with rugged pH stability from 1-12
  • 2.6 µm particles deliver increased efficiency at reduced backpressures
  • 1.7 µm particles boost performance for UHPLC methodologies
  • 5 µm particles provide extremely low pressure HPLC and Preparative purification solution
  • Seamless scalability between all three particle sizes
PhaseParticle Sizes (µm)Pore Size (Å)Recommended Use
Oligo-MS1.7, 2.6100Rapid LC/MS analysis and QC of synthetic oligonucleotide research reagents and therapeutics
Oligo-RP3, 5, 10110Purification of synthetic oligonucleotide mixtures
Oligo-WAX10400Preparative purification of synthetic oligonucleotide mixtures
Oligo-XT1.7, 2.6, 5100
Phase: Particle Size: Pore Size: Length: Internal Diameter:

Part Number:00D-4745-P0-AX

Description:Clarity® 5 µm Oligo-XT, AXIA Packed, LC Column 100 x 21.2 mm, Ea

Required Holder:

Stationary Phase:

Solid Support:

Format:AXIAL Compression

Separation Mode:

Recommended Use:

USP Designation:

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