Purification Products

Clarity HPLC Information

Purification and Analysis of Synthetic Oligonucleotides

The Clarity BioSolutions LC portfolio includes novel RP-LC and IEX-LC columns for purifying and characterizing synthetic DNA / RNA used in biological research, therapeutic development, and biochemical manufacturing.


• Clarity Oligo-XT: High Efficiency LC/MS Analysis Scaling Directly to LC Purification


Clarity Oligo-MS™: LC/MS analysis


Clarity Oligo-RP™: RP-LC purification and analysis


Clarity Oligo-WAX™: IEX-LC purification



Particle Sizes (µm)3, 5, 10
Pore Size (Å)110
Compare All Phases

Oligo-RP Phase Information

Quick Salt Removal

Clarity RP-Desalting™ tubes utilize reversed phase, in lieu of size exclusion, to eliminate salt and reagent from trityl-off synthetic oligo mixtures in order to capitalize on the speed and loading capacity benefits.

  • ~70 % purity and ~80 % recovery of target oligo
  • Economical and disposable format
  • Amenable to vacuum manifold for quick desalting
PhaseParticle Sizes (µm)Pore Size (Å)Recommended Use
Oligo-MS1.7, 2.6100Rapid LC/MS analysis and QC of synthetic oligonucleotide research reagents and therapeutics
Oligo-RP3, 5, 10110Purification of synthetic oligonucleotide mixtures
Oligo-WAX10400Preparative purification of synthetic oligonucleotide mixtures
Oligo-XT1.7, 2.6, 5100
Phase: Particle Size: Pore Size: Length: Internal Diameter:

Part Number:00G-4442-P0-AX

Description:Clarity® 5 µm Oligo-RP, LC Column 250 x 21.2 mm, AXIA™ Packed, Ea

Required Holder:

Stationary Phase:C18

Solid Support:Fully Porous Organo-silica

Format:AXIAL Compression

Separation Mode:Reversed Phase

Recommended Use:Purification of synthetic oligonucleotide mixtures

USP Designation:L1

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