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Isolation and Purification of Synthetic Oligonucleotides
The Clarity BioSolutions sample preparation portfolio is composed of unique solid phase extraction chemistries packed in 96-well plate and cartridge formats for use with specially formulated buffers for the extraction of DNA and RNA from synthetic cocktails as well as biological matrices.
Developed to be a versatile, gentle, and extremely effective trityl-on purification process, Clarity QSP 96-well plates and cartridges deliver near impurity-free, concentrated full-length sequences.
Clarity OTX is a simple, rapid, and reproducible solution that efficiently extracts oligos from biological matrices and can be easily automated.
Using Clarity QSP cartridges, we were able to substantially minimize if not eliminate depurination from occurring during purification.
Clarity QSP cartridges provide ease and efficacy not typically found in competing trityl-on purification platforms, such as the *TOP™ products.
Purify trityl-on synthetic DNA or RNA samples in 20 minutes using Clarity QSP™ 96-well plate and buffer system. Final elution delivers >90 % typical purities/recoveries for in vivo applications and downstream analysis by LC/MS or CE.
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