A Unified Sample Preparation Procedure for General Unknown Screening (GUS) of Compounds in Whole Blood Samples

The identification of drugs from whole blood by high resolution mass spectrometer serves as an effective screening tool in both clinical and forensic labs. In addition, whole blood presents a challenging matrix that often requires an elaborate sample preparation procedure. The objectives of this work was to: • Develop a universal sample preparation procedure for whole blood samples to: lyse the erythrocytes, precipitate the majority of plasma proteins, and remove high levels of phopholipids present in the sample • Neutralize the undesirable effect of strong solvent
Document Type:
Technical Notes
Clinical Forensics/Toxicology
HPLC / UHPLC Sample Prep
Kinetex Phree
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