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Impact of pH on Improving Purity and Yield for Preparative Separations (TN-1050)


Abstract:
ncrease yield and fraction purity for basic compounds using Gemini-NX preparative columns. By neutralizing the charge on basic compounds under high pH mobile phase, resolution and retention are significantly improved. Baseline resolution can be maintained even after increasing sample concentration 10x
Document Type:
Technical Notes
Industries:
Pharmaceutical/Biopharmaceutical
Techniques:
Preparative
Brands:
Axia Gemini
PDF Link:
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