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Aeris HPLC Information


UHPLC/HPLC Core-Shell Technology for BioSeparations

Core-shell particle technology provides striking increases in peak capacity and resolution at lower backpressure, giving chromatographers the ability to achieve ultra-high performance on ANY system, from  UHPLC to HPLC to PREP.

A uniform porous silica layer is grown around a solid, spherical silica core, providing effective retention and selectivity with improved resolution, speed, and recovery. Next, optimizing the pore size and shell thickness for intact proteins or smaller peptide fragments provides well-defined depth penetration of biomolecules leading to maximum separation power.

TEM and SEM of Aeris PEPTIDE 3.6 µm Core-Shell Particles

The precise architecture of core-shell particles provides dramatic leaps in performance in TWO important ways:

The thin, porous layer, or "shell", decreases the diffusion path length, thus reducing the time it takes for biomolecules to adsorb/desorb into and out of the particles.
Uniform sizing and shape of the particles along with tight packing specifications reduces losses in efficiency and performance due to band broadening.

The result is:

  • 3.6 µm and 2.6 µm core-shell particles that can perform like sub-2 μm columns on both HPLC and UHPLC systems at a fraction of the pressure
  • 2.6 µm and 1.7 µm core-shell particles that can provide higher peak capacities compared to fully porous sub-2 μm columns on UHPLC systems

WIDEPORE XB-C8


WIDEPORE XB-C8 Phase Information


Moderate Hydrophobicity Recommended for:

  • Large proteins
  • Moderately hydrophobic proteins
  • Monoclonal antibodies
  • Glycosylated proteins
  • High temperature separations
Document Type:
Document Type Title
Technical Notes Intact IgG Separations by HPLC/UHPLC (TN-1110) Add to My Documents
Brochures Aeris Core-Shell Technology for Proteins and Peptides Add to My Documents
Other Cross Reference Guide By Supplier - Landscape View Add to My Documents
Brochures Improve Your Bioanalytical Assays Today Add to My Documents
Technical Notes Intact Biogeneric Protein Separations by HPLC/UHPLC (TN-1111) Add to My Documents
Webinar On-Demand BioSeparations Webinar from Phenomenex and C&E News Add to My Documents
Brochures Online BioSeparations Handbook Add to My Documents
Technical Notes Post-Translational Modifications of Intact IgG by HPLC/UHPLC and GFC/SEC (TN-1118) Add to My Documents
Technical Notes Intact IgG by HPLC/UHPLC (TN-1123) Add to My Documents
Technical Notes Peptide Mapping by HPLC (TN-1124) Add to My Documents
Brochures 2015 Axia Brochure Add to My Documents
Supporting Docs Aeris Column Care Guide Add to My Documents
Supporting Docs Important Tips for Optimizing Aeris Add to My Documents
Technical Notes LC/MS/MS Analysis of Immunosuppressants from Whole Blood (TN-1169) Add to My Documents
Technical Notes Recommendations for Transferring Peptide Mapping Methods to LC/MS Using Core-Shell Columns (TN-1181) Add to My Documents
MSDS Safety Data Sheet for Silica-Based HPLC Columns Add to My Documents
Brochures SecurityGuard ULTRA Brochure Add to My Documents
Supporting Docs Allowable Adjustments to Pharmacopoeia Methods Add to My Documents
Supporting Docs Meeting All Your PREP Needs Add to My Documents
Supporting Docs Meeting All Your SFC Needs Add to My Documents
Other Protein and Peptide Users Guide Add to My Documents
Technical Notes SecurityGuard ULTRA Dramatically Extends UHPLC Column Lifetimes (TN-1125) Add to My Documents
Brochures SecurityGuard Column Protection Family Brochure (UHPLC, HPLC, PREP, SFC) Add to My Documents
Supporting Docs HPLC Column Care Guide Add to My Documents
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