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How does sorbent pore size affect SPE?

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STRATA STRATA-X SAMPLE PREP SPE

Last Updated: 4/17/2014

Sorbent-analyte interactions take place inside the pores.  The average pore size of regular polymeric and silica-based SPE material is 60-85 Å, which restricts access for molecules larger than 15 kDa. Analytes must be able to fit in the pores in order to interact with the sorbent.

Large pore sorbents are available in 260-300 Å for molecules with molecular weights >15 kD.

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