Doxylamine impurity profile on Kinetex 2.6 µm EVO C18
LC Conditions
Column
Kinetex 2.6 µm EVO C18 100 Å, LC Column 50 x 2.1 mm, Ea
Brand
Kinetex
Part No
00B-4725-AN
Phase Name
EVO C18
Elution Type
Gradient
Mobile Phase
A: 20 mM ammonium bicarbonate pH 10.0
B: Acetonitrile
Gradient Profile
Step No.
Time(min)
%A
%B
1
0
95
5
2
5
5
95
Flow Rate
0.70 mL/min
Temperature
22°C
Detection
UV-Vis Abs.-Variable Wave.(UV) @ (22°C)
Detection Info
Sample Notes
Forced degradation protocol: Reconstitute 1 mg of cefaclor neat standard with 1.0 mL of 1 M HCl. Heat the solution at 60 ºC for 6 hours then neutralize with 1.0 mL of 1 M NaOH. Refrigerate until ready to inject.
Order Items Used in This Application
- 1. Doxylamine
-OEChem-06211003152D<br><br> 42 43 0 1 0 0 0 0 0999 V2000<br> 4.0000 0.0000 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.0000 -1.7320 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.8660 -1.5000 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.0000 0.0000 0.0000 C 0 0 3 0 0 0 0 0 0 0 0 0<br> 3.0000 1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.0000 -1.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.0000 0.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.5000 -0.8660 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.5000 -0.8660 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.1340 1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.8660 1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.1340 -1.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.1340 2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.8660 2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.1340 -2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.0000 3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.0000 -1.7320 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.5000 -2.5981 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.8660 -2.5000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.0000 -3.0000 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.0000 0.6200 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1.3800 0.0000 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.0000 -0.6200 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.9174 -1.0781 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.6077 -1.4766 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.0826 -0.6540 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.3923 -0.2554 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1.5970 1.1900 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.4030 1.1900 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1.5970 -1.1900 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1.5970 2.8100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.4030 2.8100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1.5970 -2.8100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.0000 3.6200 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.0000 -2.3521 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.6200 -1.7320 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.0000 -1.1120 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.9631 -2.2881 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.1900 -3.1350 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.0369 -2.9081 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.4030 -2.8100 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.0000 -3.6200 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1 4 1 0 0 0 0<br> 1 8 1 0 0 0 0<br> 2 9 1 0 0 0 0<br> 2 17 1 0 0 0 0<br> 2 18 1 0 0 0 0<br> 3 6 1 0 0 0 0<br> 3 19 2 0 0 0 0<br> 4 5 1 0 0 0 0<br> 4 6 1 0 0 0 0<br> 4 7 1 0 0 0 0<br> 5 10 2 0 0 0 0<br> 5 11 1 0 0 0 0<br> 6 12 2 0 0 0 0<br> 7 21 1 0 0 0 0<br> 7 22 1 0 0 0 0<br> 7 23 1 0 0 0 0<br> 8 9 1 0 0 0 0<br> 8 24 1 0 0 0 0<br> 8 25 1 0 0 0 0<br> 9 26 1 0 0 0 0<br> 9 27 1 0 0 0 0<br> 10 13 1 0 0 0 0<br> 10 28 1 0 0 0 0<br> 11 14 2 0 0 0 0<br> 11 29 1 0 0 0 0<br> 12 15 1 0 0 0 0<br> 12 30 1 0 0 0 0<br> 13 16 2 0 0 0 0<br> 13 31 1 0 0 0 0<br> 14 16 1 0 0 0 0<br> 14 32 1 0 0 0 0<br> 15 20 2 0 0 0 0<br> 15 33 1 0 0 0 0<br> 16 34 1 0 0 0 0<br> 17 35 1 0 0 0 0<br> 17 36 1 0 0 0 0<br> 17 37 1 0 0 0 0<br> 18 38 1 0 0 0 0<br> 18 39 1 0 0 0 0<br> 18 40 1 0 0 0 0<br> 19 20 1 0 0 0 0<br> 19 41 1 0 0 0 0<br> 20 42 1 0 0 0 0<br>M END
Compound Name
Doxylamine
CID
3162
Molecular Formula
C17H22N2O
Molecular Weight
270
No. Hydrogen Bond Acceptors
3
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