Optimized method of Valsartan and Sacubitril on Kinetex F5 column
LC Conditions
Column
Kinetex 5 µm F5 100 Å, LC Column 250 x 4.6 mm, Ea
Brand
Kinetex
Part No
00G-4724-E0
Phase Name
F5
Elution Type
Gradient
Mobile Phase
A: pH 2.5 10mM potassium dihydrogen phosphate
B: Acetonitrile
Gradient Profile
Step No.
Time(min)
%A
%B
1
0
65
35
2
25
65
35
3
32
10
90
4
35
10
90
5
38
65
35
6
45
65
35
Flow Rate
0.80 mL/min
Temperature
40°C
System
Waters HPLC System Waters ACQUITY UPLC H-Class
Detection
UV-Vis Abs.-Diode Array (PDA)
Detection Info
Order Items Used in This Application
- 1. Valsartan
- 2. Sacubutril
-OEChem-05151001052D<br><br> 61 63 0 1 0 0 0 0 0999 V2000<br> 2.5369 1.4798 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.0010 -0.5202 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.4030 -0.0202 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.1350 0.9798 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 9.5222 1.5676 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 11.1402 1.5676 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 9.8312 2.5186 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 10.8312 2.5186 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.2690 1.4798 0.0000 C 0 0 1 0 0 0 0 0 0 0 0 0<br> 4.2690 2.4798 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.0010 1.4798 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.1350 -0.0202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.4030 2.9798 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.1350 2.9798 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.2690 -0.5202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.4030 0.9798 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.8671 0.9798 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.2690 -1.5202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.4030 -2.0202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.8671 -0.0202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.7331 1.4798 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 8.5991 -0.0202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.7331 -0.5202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 8.5991 0.9798 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.4030 -3.0202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 9.4651 -0.5202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 10.3312 -0.0202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 9.4651 -1.5202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 11.1972 -0.5202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 10.3312 -2.0202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 10.3312 0.9798 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 11.1972 -1.5202 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.8059 1.7898 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.2690 3.0998 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.3996 1.9547 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.6025 1.9547 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.7130 3.5167 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.8660 3.2898 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.0930 2.4428 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.4450 2.4428 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.6720 3.2898 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.8250 3.5167 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.0569 0.0624 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.6584 -0.6279 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.4810 -2.1028 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.8796 -1.4126 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.1909 -1.4376 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.7924 -2.1279 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.3301 -0.3302 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.7331 2.0998 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.7331 -1.1402 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 9.1360 1.2898 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.7830 -3.0202 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.4030 -3.6402 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.0230 -3.0202 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.0000 1.1698 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 8.9282 -1.8302 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 11.7341 -0.2102 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 10.3312 -2.6402 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 11.7341 -1.8302 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 9.4667 3.0202 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1 16 1 0 0 0 0<br> 1 56 1 0 0 0 0<br> 2 12 2 0 0 0 0<br> 3 16 2 0 0 0 0<br> 9 4 1 6 0 0 0<br> 4 11 1 0 0 0 0<br> 4 12 1 0 0 0 0<br> 5 7 1 0 0 0 0<br> 5 31 2 0 0 0 0<br> 6 8 2 0 0 0 0<br> 6 31 1 0 0 0 0<br> 7 8 1 0 0 0 0<br> 7 61 1 0 0 0 0<br> 9 10 1 0 0 0 0<br> 9 16 1 0 0 0 0<br> 9 33 1 0 0 0 0<br> 10 13 1 0 0 0 0<br> 10 14 1 0 0 0 0<br> 10 34 1 0 0 0 0<br> 11 17 1 0 0 0 0<br> 11 35 1 0 0 0 0<br> 11 36 1 0 0 0 0<br> 12 15 1 0 0 0 0<br> 13 37 1 0 0 0 0<br> 13 38 1 0 0 0 0<br> 13 39 1 0 0 0 0<br> 14 40 1 0 0 0 0<br> 14 41 1 0 0 0 0<br> 14 42 1 0 0 0 0<br> 15 18 1 0 0 0 0<br> 15 43 1 0 0 0 0<br> 15 44 1 0 0 0 0<br> 17 20 2 0 0 0 0<br> 17 21 1 0 0 0 0<br> 18 19 1 0 0 0 0<br> 18 45 1 0 0 0 0<br> 18 46 1 0 0 0 0<br> 19 25 1 0 0 0 0<br> 19 47 1 0 0 0 0<br> 19 48 1 0 0 0 0<br> 20 23 1 0 0 0 0<br> 20 49 1 0 0 0 0<br> 21 24 2 0 0 0 0<br> 21 50 1 0 0 0 0<br> 22 23 2 0 0 0 0<br> 22 24 1 0 0 0 0<br> 22 26 1 0 0 0 0<br> 23 51 1 0 0 0 0<br> 24 52 1 0 0 0 0<br> 25 53 1 0 0 0 0<br> 25 54 1 0 0 0 0<br> 25 55 1 0 0 0 0<br> 26 27 1 0 0 0 0<br> 26 28 2 0 0 0 0<br> 27 29 2 0 0 0 0<br> 27 31 1 0 0 0 0<br> 28 30 1 0 0 0 0<br> 28 57 1 0 0 0 0<br> 29 32 1 0 0 0 0<br> 29 58 1 0 0 0 0<br> 30 32 2 0 0 0 0<br> 30 59 1 0 0 0 0<br> 32 60 1 0 0 0 0<br>M END
Compound Name
Valsartan
CID
60846
Molecular Formula
C24H29N5O3
Molecular Weight
435
No. Hydrogen Bond Acceptors
6
No. Hydrogen Bond Donors
2
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