USP Rivaroxaban Assay and Organic Impurities - Standard Solution Assay run on run on Waters® ACQUITY® H-Class
LC Conditions
Column
Luna Omega 3 µm C18 100 Å, LC Column 150 x 3.0 mm, Ea
Brand
Luna Omega
Part No
00F-4784-Y0
Phase Name
C18
Elution Type
Gradient
Mobile Phase
A: Buffer(10mM potassium dihydrogen phosphate, 5.3mM sodium hexanesulfonate, 3.77mM phosphoric acid in water)/Methanol (95:5)
B: ACN
Gradient Profile
Step No.
Time(min)
%A
%B
1
0
98
2
2
2.16
98
2
3
7.3
84
16
4
21.87
64
36
5
32.16
20
80
6
32.25
98
2
7
39
98
2
Flow Rate
1.00 mL/min
Temperature
60°C
System
Waters ACQUITY UPLC H-Class Waters ACQUITY UPLC H-Class
Detection
LC/UV (DAD, PDA) @ 250 nm (nanometers)
Detection Info
Sample Notes
Solution B: 5.3mM sodium hexane sulfonate, 3.77mM phosphoric acid in water Diluent: Acetonitrile and solution B (40:60) Standard solution: 0.5 mg/mL of USP Rivaroxaban RS in Diluent peak no. 1 analyte name: standard solution RT (min): 16.895 conc.: 0.5mg/mL
Order Items Used in This Application
- 1. Rivaroxaban
-OEChem-04281017132D<br><br> 47 50 0 1 0 0 0 0 0999 V2000<br> 3.3625 6.7856 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.9013 5.0644 0.0000 S 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.7634 0.7532 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.2634 -6.7856 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.0234 -0.5069 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.5313 -4.7856 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.0000 3.1802 0.0000 O 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.2634 -0.7856 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.2634 -4.7856 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.5823 2.4758 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.7634 0.7532 0.0000 C 0 0 2 0 0 0 0 0 0 0 0 0<br> 3.4543 -0.1979 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.1756 1.5622 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.2634 -1.7856 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.0724 -0.1979 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.2634 -3.7856 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.1294 -5.2856 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.3973 -2.2856 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.1294 -2.2856 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.3973 -3.2856 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.1294 -3.2856 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.1294 -6.2856 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.3973 -5.2856 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.3973 -6.2856 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.9945 3.2848 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.4013 4.1983 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.3794 4.4062 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.4839 5.4008 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.5704 5.8075 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.0448 1.3056 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.8879 0.0543 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.1443 -0.7348 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.6616 1.9089 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.7449 1.1162 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.7400 -5.3933 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.3414 -4.7030 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.8604 -1.9756 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.6663 -1.9756 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.8604 -3.5956 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.6663 -3.5956 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.1989 2.5406 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.3414 -6.8682 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.7400 -6.1780 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.7868 -6.1780 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.1853 -6.8682 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.8402 3.9914 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.0209 5.7108 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1 29 1 0 0 0 0<br> 2 26 1 0 0 0 0<br> 2 29 1 0 0 0 0<br> 3 11 1 0 0 0 0<br> 3 15 1 0 0 0 0<br> 4 22 1 0 0 0 0<br> 4 24 1 0 0 0 0<br> 5 15 2 0 0 0 0<br> 6 23 2 0 0 0 0<br> 7 25 2 0 0 0 0<br> 8 12 1 0 0 0 0<br> 8 14 1 0 0 0 0<br> 8 15 1 0 0 0 0<br> 9 16 1 0 0 0 0<br> 9 17 1 0 0 0 0<br> 9 23 1 0 0 0 0<br> 10 13 1 0 0 0 0<br> 10 25 1 0 0 0 0<br> 10 41 1 0 0 0 0<br> 11 12 1 0 0 0 0<br> 11 13 1 6 0 0 0<br> 11 30 1 0 0 0 0<br> 12 31 1 0 0 0 0<br> 12 32 1 0 0 0 0<br> 13 33 1 0 0 0 0<br> 13 34 1 0 0 0 0<br> 14 18 2 0 0 0 0<br> 14 19 1 0 0 0 0<br> 16 20 2 0 0 0 0<br> 16 21 1 0 0 0 0<br> 17 22 1 0 0 0 0<br> 17 35 1 0 0 0 0<br> 17 36 1 0 0 0 0<br> 18 20 1 0 0 0 0<br> 18 37 1 0 0 0 0<br> 19 21 2 0 0 0 0<br> 19 38 1 0 0 0 0<br> 20 39 1 0 0 0 0<br> 21 40 1 0 0 0 0<br> 22 42 1 0 0 0 0<br> 22 43 1 0 0 0 0<br> 23 24 1 0 0 0 0<br> 24 44 1 0 0 0 0<br> 24 45 1 0 0 0 0<br> 25 26 1 0 0 0 0<br> 26 27 2 0 0 0 0<br> 27 28 1 0 0 0 0<br> 27 46 1 0 0 0 0<br> 28 29 2 0 0 0 0<br> 28 47 1 0 0 0 0<br>M END
Compound Name
Rivaroxaban
CID
9875401
Molecular Formula
C19H18ClN3O5S
Molecular Weight
435
No. Hydrogen Bond Acceptors
5
No. Hydrogen Bond Donors
1
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