Imipramine - USP Acceptable Modified Method
LC Conditions
Official Method
USP L01
Column
Luna 5 µm C18(2) 100 Å, LC Column 150 x 4.6 mm, Ea
Brand
Luna
Part No
00F-4252-E0
Phase Name
C18(2)
Elution Type
Isocratic
Mobile Phase
A: 0.06M sodiumperchlorate, pH 2.0
B: Acetonitrile
C: Triethylamine
Gradient Profile
Step No.
Time(min)
%A
%B
1
0
62.5
37.5
Flow Rate
2.00 mL/min
Temperature
22°C
Detection
UV-Vis Abs.-Variable Wave.(UV) @ (22°C)
Detection Info
Sample Notes
SecurityGuard™ Guard Cartridge System extends column lifetime. - SecurityGuard Cartridges, C18 4 x 3.0mm, 10/Pk Part No.: AJ0-4287 - Holder Part No.: KJ0-4282
Order Items Used in This Application
- 1. Imipramine
- 2. Desipramine
-OEChem-06211003152D<br><br> 45 47 0 0 0 0 0 0 0999 V2000<br> 4.8830 0.9047 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.1509 -2.0953 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.8830 -0.0953 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.9820 1.3386 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.7840 1.3385 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.3830 3.0953 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.3830 3.0953 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.7595 2.3135 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.0065 2.3135 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.0170 -0.5953 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.0169 -1.5953 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.2295 0.6184 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.5365 0.6184 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.7690 2.6358 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.9970 2.6358 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.2318 0.9177 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.5342 0.9177 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.0000 1.9333 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.7660 1.9332 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.1509 -3.0953 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.2849 -1.5953 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.0950 -0.6779 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.4936 0.0123 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.5210 3.6998 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.8244 3.3643 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.9416 3.3643 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 5.2450 3.6998 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.8049 -0.0127 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.4064 -0.7030 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.2290 -2.1779 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 4.6275 -1.4877 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.3744 0.0156 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 6.3916 0.0155 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.6380 3.2418 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.1280 3.2418 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1.7789 0.4943 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 7.9871 0.4942 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1.4083 2.1183 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 8.3578 2.1182 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.5309 -3.0953 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.1509 -3.7153 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 3.7709 -3.0953 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 2.5949 -1.0584 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1.7480 -1.2853 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1.9749 -2.1322 0.0000 H 0 0 0 0 0 0 0 0 0 0 0 0<br> 1 3 1 0 0 0 0<br> 1 4 1 0 0 0 0<br> 1 5 1 0 0 0 0<br> 2 11 1 0 0 0 0<br> 2 20 1 0 0 0 0<br> 2 21 1 0 0 0 0<br> 3 10 1 0 0 0 0<br> 3 22 1 0 0 0 0<br> 3 23 1 0 0 0 0<br> 4 8 1 0 0 0 0<br> 4 12 2 0 0 0 0<br> 5 9 1 0 0 0 0<br> 5 13 2 0 0 0 0<br> 6 7 1 0 0 0 0<br> 6 8 1 0 0 0 0<br> 6 24 1 0 0 0 0<br> 6 25 1 0 0 0 0<br> 7 9 1 0 0 0 0<br> 7 26 1 0 0 0 0<br> 7 27 1 0 0 0 0<br> 8 14 2 0 0 0 0<br> 9 15 2 0 0 0 0<br> 10 11 1 0 0 0 0<br> 10 28 1 0 0 0 0<br> 10 29 1 0 0 0 0<br> 11 30 1 0 0 0 0<br> 11 31 1 0 0 0 0<br> 12 16 1 0 0 0 0<br> 12 32 1 0 0 0 0<br> 13 17 1 0 0 0 0<br> 13 33 1 0 0 0 0<br> 14 18 1 0 0 0 0<br> 14 34 1 0 0 0 0<br> 15 19 1 0 0 0 0<br> 15 35 1 0 0 0 0<br> 16 18 2 0 0 0 0<br> 16 36 1 0 0 0 0<br> 17 19 2 0 0 0 0<br> 17 37 1 0 0 0 0<br> 18 38 1 0 0 0 0<br> 19 39 1 0 0 0 0<br> 20 40 1 0 0 0 0<br> 20 41 1 0 0 0 0<br> 20 42 1 0 0 0 0<br> 21 43 1 0 0 0 0<br> 21 44 1 0 0 0 0<br> 21 45 1 0 0 0 0<br>M END
Compound Name
Imipramine
CID
3696
Molecular Formula
C19H24N2
Molecular Weight
280
No. Hydrogen Bond Acceptors
2
Similar Applications
PS App: Effect of pH on Waters ACQUITY CSH 1.7 µm C18 50 x 2.1 mm (20 mM Sodium Phosphate pH 7.0)
26854
PS App: Effect of pH on Waters CORTECS C18+ 2.7 µm 50 x 2.1 mm (20 mM Sodium Phosphate pH 7.0)
26853
Reversed Phase
PS App: Effect of pH on Luna Omega 1.6 µm PS C18 50 x 2.1 mm (20 mM Sodium Phosphate pH 7.0)
Luna Omega 1.6µm PS C18 100Å, LC Column 50 x 2.1 mm, EA
26852
Reversed Phase
PS App: Effect of pH on Kinetex 2.6 µm PS C18 50 x 2.1 mm (20 mM Sodium Phosphate pH 7.0)
Kinetex 2.6 µm PS C18 100 Å, LC Column 50 x 2.1 mm, Ea
26851
PS App: Effect of pH on Waters ACQUITY CSH 1.7u C18 50 x 2.1 mm (20 mM Sodium Acetate pH 5.0)
26850
PS App: Effect of pH on Waters CORTECS C18+ 2.7 µm 50 x 2.1 mm (20 mM Sodium Acetate pH 5.0)
26849
Reversed Phase
PS App: Effect of pH on Luna Omega 1.6 µm PS C18 50 x 2.1 mm (20 mM Sodium Acetate pH 5.0)
Luna Omega 1.6µm PS C18 100Å, LC Column 50 x 2.1 mm, EA
26848
Reversed Phase
PS App: Effect of pH on Kinetex 2.6 µm PS C18 50 x 2.1 mm (20 mM Sodium Acetate pH 5.0)
Kinetex 2.6 µm PS C18 100 Å, LC Column 50 x 2.1 mm, Ea
26847
PS App: Effect of pH on Waters ACQUITY CSH 1.7 µm C18 50 x 2.1 mm (0.1% Formic Acid)
26846
PS App: Effect of pH on Waters CORTECS C18+ 2.7 µm 50 x 2.1 mm (0.1% Formic Acid)
26845
Reversed Phase
PS App: Effect of pH on Luna Omega 1.6 µm PS-C18 50 x 2.1 mm (0.1% Formic Acid)
Luna Omega 1.6µm PS C18 100Å, LC Column 50 x 2.1 mm, EA
26844
Reversed Phase
PS App: Effect of pH on Kinetex 2.6 µm PS C18 50 x 2.1 mm (0.1% Formic Acid)
Kinetex 2.6 µm PS C18 100 Å, LC Column 50 x 2.1 mm, Ea
26843
TCAs (Tricyclic Antidepressants) on Waters ACQUITY CSH 1.7 µm C18 50 x 2.1 mm
26836
TCAs (Tricyclic Antidepressants) on Waters CORTECS C18+ 2.7 µm 50 x 2.1 mm
26835
Reversed Phase
TCAs (Tricyclic Antidepressants) on Kinetex 2.6 µm C18 50 x 2.1 mm
Kinetex 2.6 µm C18 100 Å, LC Column 50 x 2.1 mm, Ea
26834
Reversed Phase
TCAs (Tricyclic Antidepressants) on Kinetex 2.6 µm PS-C18 50 x 2.1 mm
Kinetex 2.6 µm PS C18 100 Å, LC Column 50 x 2.1 mm, Ea
26833
Reversed Phase
TCAs (Tricyclic Antidepressants) on Luna Omega 1.6 µm C18 50 x 2.1 mm
Luna Omega 1.6µm C18 100Å, LC Column 50 x 2.1 mm, EA
26832
Reversed Phase
TCAs (Tricyclic Antidepressants) on Luna Omega 1.6 µm PS C18 50 x 2.1 mm
Luna Omega 1.6µm PS C18 100Å, LC Column 50 x 2.1 mm, EA
26831
Reversed Phase
Fast Screening Method for 86 Forensic Analytes in Human Urine by LC-MS/MS
Luna 5 µm C18(2) 100 Å, LC Column 50 x 2 mm, Ea
25864
Reversed Phase
Imipramine and Amitriptyline Loading on Kinetex 2.6um C18 50x4.6mm using Waters Acquity I class UHPLC- clone
Kinetex 2.6 µm C18 100 Å, LC Column 50 x 4.6 mm, Ea
25553
Reversed Phase
Imipramine and Amitriptyline Loading on Kinetex 2.6µm PS C18 50x4.6mm using Waters ACQUITY I Class UPLC
Kinetex 2.6 µm PS C18 100 Å, LC Column 50 x 4.6 mm, Ea
25512
Reversed Phase
Tricyclic Antidepressants Panel by LC-MS/MS with Kinetex 2.6 um PS C18
Kinetex 2.6 µm PS C18 100 Å, LC Column 100 x 2.1 mm, Ea
25493
Reversed Phase
TCAs on Luna Omega 3u PS C18 100x4.6mm
Luna Omega 3 µm PS C18 100 Å, LC Column 100 x 4.6 mm, Ea
24052
Reversed Phase
7.5 min Pain Panel on Kinetex 2.6µm Biphenyl, 30x2.1mm ESI+
Kinetex 2.6 µm Biphenyl 100 Å, LC Column 30 x 2.1 mm, Ea
23560
Reversed Phase
Fast Pain Panel ESI+
Kinetex 2.6 µm Biphenyl 100 Å, LC Column 30 x 2.1 mm, Ea
23384
Reversed Phase
TCAs at neutral pH Kinetex 5u EVO C18 150x4.6mm
Kinetex 5 µm EVO C18 100 Å, LC Column 150 x 4.6 mm, Ea
22779
Chiral
Effect of Modifier and Additive on Enantioseparation of Trimipramine on Lux Cellulose-2
Lux 3 µm Cellulose-2, LC Column 150 x 2 mm, Ea
19366
Reversed Phase
TCA's UV Kinetex 1.7µm C18 50x2.1mm Acquity UPLC
Kinetex 1.7 µm C18 100 Å, LC Column 50 x 2.1 mm, Ea
19310
Reversed Phase
TCA's LC/MS/MS Kinetex 1.7µm C18 50x2.1mm Agilent 1200
Kinetex 1.7 µm C18 100 Å, LC Column 50 x 2.1 mm, Ea
19309
Reversed Phase
TCA's LC/MS/MS Kinetex 1.7µm C18 50x2.1mm Agilent 1200
Kinetex 1.7 µm C18 100 Å, LC Column 50 x 2.1 mm, Ea
19308
Reversed Phase
TCA's LC/MS/MS Kinetex 1.7µm C18 50x2.1mm Agilent 1200
Kinetex 1.7 µm C18 100 Å, LC Column 50 x 2.1 mm, Ea
19307
Reversed Phase
TCA's LC/MS/MS Kinetex 1.7µm C18 50x2.1mm Agilent 1200
Kinetex 1.7 µm C18 100 Å, LC Column 50 x 2.1 mm, Ea
19306
Standard
Antidepressants (Underivatized) on ZB-1701, 15 m x 0.25 mm x 0.25 µm
Zebron ZB-1701, GC Cap. Column 15 m x 0.25 mm x 0.25 µm, Ea
19295
Reversed Phase
Competitor Comparison-Tricyclic Antideprassent on Kinetex 2.6 µm C18 100 x 4.6mm
Kinetex 2.6 µm C18 100 Å, LC Column 100 x 4.6 mm, Ea
19230
Application Specific
Drug screen by MSD on a ZB-Drug1
Zebron ZB-Drug-1, GC Cap. Column 10 m x 0.18 mm x 0.18 µm, Ea
18175
Chiral
Trimipramne on Lux 5µ Cellulose-1 in RP 60% CH3CN
Lux 5 µm Cellulose-1, LC Column 250 x 4.6 mm, Ea
17870
Chiral
Trimipramne on Lux 5µ Cellulose-1 in RP 50% CH3CN
Lux 5 µm Cellulose-1, LC Column 250 x 4.6 mm, Ea
17869
Reversed Phase
MercuryMS - Luna 3µm C18(2) 20 x 2.0mm (mini column) for Tricyclics in Plasma by LC/MS/MS
Luna 3 µm C18(2) 100 Å, LC Column 20 x 2 mm, Ea
16043
MercuryMS - Synergi 2.5µm Fusion-RP 20 x 2.0mm for Tricyclics in Plasma by LC/MS/MS
16041
Drug Screen on Zebron ZB-1MS 12m x 0.20mm x 0.33um
15869
Standard
Drug Screen on Zebron ZB-5MS 20m x 0.18mm x 0.18um
Zebron ZB-5MS, GC Cap. Column 20 m x 0.18 mm x 0.18 µm, Ea
15868
Drug Screen on Zebron ZB-1MS 20m x 0.18mm x 0.18um
15867