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Simultaneous Detection of Tricarboxylic Acid Cycle Intermediates using LC-MS/MS with a Synergi Fusion-RP HPLC Column (TN-1241)
In this technical note, the goal was to develop an LC-MS/MS assay able to analyze tricarboxylic acids out of a human serum albumin matrix over a dynamic range of concentrations and demonstrate acceptable accuracy and precision in reference to GLP guidance. In addition, the reference method should be a fast and reproducible assay, easily implemented in most laboratories with standard analytical equipment.
Simultaneous Detection of Tricarboxylic Acid Cycle Intermediates using LC-MS/MS with a Synergi Fusion-RP HPLC Column (TN-1241)
In this technical note, the goal was to develop an LC-MS/MS assay able to analyze tricarboxylic acids out of a human serum albumin matrix over a dynamic range of concentrations and demonstrate acceptable accuracy and precision in reference to GLP guidance. In addition, the reference method should be a fast and reproducible assay, easily implemented in most laboratories with standard analytical equipment.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Reversed Phase
Phases:
Simultaneous Detection of Tricarboxylic Acid Cycle Intermediates using LC-MS/MS with a Synergi Fusion-RP HPLC Column (TN-1241)
In this technical note, the goal was to develop an LC-MS/MS assay able to analyze tricarboxylic acids out of a human serum albumin matrix over a dynamic range of concentrations and demonstrate acceptable accuracy and precision in reference to GLP guidance. In addition, the reference method should be a fast and reproducible assay, easily implemented in most laboratories with standard analytical equipment.
| Target Industries: | Biopharmaceutical Analysis, Clinical Research, Pharmaceutical |
| Techniques: | HPLC, HPLC Reversed Phase |
| Brands: | Synergi |
| Separation Modes: | Reversed Phase |
| Phases: | Synergi Fusion-RP |
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.