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Simultaneous Detection of Tricarboxylic Acid Cycle Intermediates using LC-MS/MS with a Synergi Fusion-RP HPLC Column (TN-1241)
In this technical note, the goal was to develop an LC-MS/MS assay able to analyze tricarboxylic acids out of a human serum albumin matrix over a dynamic range of concentrations and demonstrate acceptable accuracy and precision in reference to GLP guidance. In addition, the reference method should be a fast and reproducible assay, easily implemented in most laboratories with standard analytical equipment.
Simultaneous Detection of Tricarboxylic Acid Cycle Intermediates using LC-MS/MS with a Synergi Fusion-RP HPLC Column (TN-1241)
In this technical note, the goal was to develop an LC-MS/MS assay able to analyze tricarboxylic acids out of a human serum albumin matrix over a dynamic range of concentrations and demonstrate acceptable accuracy and precision in reference to GLP guidance. In addition, the reference method should be a fast and reproducible assay, easily implemented in most laboratories with standard analytical equipment.
Simultaneous Detection of Tricarboxylic Acid Cycle Intermediates using LC-MS/MS with a Synergi Fusion-RP HPLC Column (TN-1241)
In this technical note, the goal was to develop an LC-MS/MS assay able to analyze tricarboxylic acids out of a human serum albumin matrix over a dynamic range of concentrations and demonstrate acceptable accuracy and precision in reference to GLP guidance. In addition, the reference method should be a fast and reproducible assay, easily implemented in most laboratories with standard analytical equipment.