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Effect of Mobile Phase pH in Aggregate Analysis of Monoclonal Antibodies by Size Exclusion Chromatography using a Biozen dSEC-2 LC Column
Protein adsorption may occur in SEC methods. As such, investigating the pH of the mobile phase is critical in understanding experimental design for method optimization and robustness studies. The two monoclonal antibodies investigated in this application show little difference in chromatographic performance when running moderately high phosphate buffers and varying pH levels.

Effect of Mobile Phase pH in Aggregate Analysis of Monoclonal Antibodies by Size Exclusion Chromatography using a Biozen dSEC-2 LC Column

Protein adsorption may occur in SEC methods. As such, investigating the pH of the mobile phase is critical in understanding experimental design for method optimization and robustness studies. The two monoclonal antibodies investigated in this application show little difference in chromatographic performance when running moderately high phosphate buffers and varying pH levels.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Size Exclusion