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A Simple Approach to Method Development using Analyte LogD (TN-1236)
In this example, an ibuprofen standard was obtained and screened on 3 different reversed phase Kinetex core-shell columns at two separate pH’s, 2.0 and 8.0. This analysis demonstrates the solubility implications of the fractional composition of the ionized vs. unionized species of the drug, and how LogD is a useful and fast indicator in determining the most appropriate mobile phase pH for a given method.
A Simple Approach to Method Development using Analyte LogD (TN-1236)
In this example, an ibuprofen standard was obtained and screened on 3 different reversed phase Kinetex core-shell columns at two separate pH’s, 2.0 and 8.0. This analysis demonstrates the solubility implications of the fractional composition of the ionized vs. unionized species of the drug, and how LogD is a useful and fast indicator in determining the most appropriate mobile phase pH for a given method.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Reversed Phase
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