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PFAS Analysis Based Upon a pH-Variable LC Mobile Phase Gradient (TN-1280)
In this technical note, a new chromatographic strategy using a 100% organic system (for long chain PFAS solubility) and variable mobile phase pH to provide good chromatography for PFBA and other early eluting PFAS compounds. By staying within the confines of the NH4OAc mobile phase composition but employing pH as a variable, one can realize the potential advantages mobile phase variation allowed by EPA while avoiding the primary disadvantages. This approach could be useful in overcoming the difficulty of expanding the analyte lists of the existing PFAS methods to incorporate both the hydrophilic shorter chain compounds and the extremely hydrophobic longer chain compounds.
PFAS Analysis Based Upon a pH-Variable LC Mobile Phase Gradient (TN-1280)
In this technical note, a new chromatographic strategy using a 100% organic system (for long chain PFAS solubility) and variable mobile phase pH to provide good chromatography for PFBA and other early eluting PFAS compounds. By staying within the confines of the NH4OAc mobile phase composition but employing pH as a variable, one can realize the potential advantages mobile phase variation allowed by EPA while avoiding the primary disadvantages. This approach could be useful in overcoming the difficulty of expanding the analyte lists of the existing PFAS methods to incorporate both the hydrophilic shorter chain compounds and the extremely hydrophobic longer chain compounds.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Reversed Phase, Solid Phase Extraction
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