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Antibody Degradation on Biozen SEC | Phenomenex
This application note demonstrates the applicability of the Biozen dSEC-2 column in understanding the biophysical integrity monoclonal antibodies and related proteins. Stability studies have been shown to generate impurities that feature a degree of denaturization thus exposing some hydrophobic regions of the folded protein's interior. The hydrophilic nature of the Biozen dSEC-2 stationary phase shows favorable aggregate profiles for forced degradation work under high salt conditions which is a known challenge when working with more hydrophobic hybrid particles for these studies.
Antibody Degradation on Biozen SEC | Phenomenex
This application note demonstrates the applicability of the Biozen dSEC-2 column in understanding the biophysical integrity monoclonal antibodies and related proteins. Stability studies have been shown to generate impurities that feature a degree of denaturization thus exposing some hydrophobic regions of the folded protein's interior. The hydrophilic nature of the Biozen dSEC-2 stationary phase shows favorable aggregate profiles for forced degradation work under high salt conditions which is a known challenge when working with more hydrophobic hybrid particles for these studies.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Size Exclusion
Antibody Degradation on Biozen SEC | Phenomenex
This application note demonstrates the applicability of the Biozen dSEC-2 column in understanding the biophysical integrity monoclonal antibodies and related proteins. Stability studies have been shown to generate impurities that feature a degree of denaturization thus exposing some hydrophobic regions of the folded protein's interior. The hydrophilic nature of the Biozen dSEC-2 stationary phase shows favorable aggregate profiles for forced degradation work under high salt conditions which is a known challenge when working with more hydrophobic hybrid particles for these studies.
| Target Industries: | Biopharmaceutical Analysis |
| Techniques: | HPLC-SEC |
| Brands: | Biozen LC |
| Separation Modes: | Size Exclusion |
| Phases: | Biozen Size Exclusion Chromatography (dSEC) Columns |
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.