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Extraction of 2’-MOE Phosphorothioate from Tissue Using Clarity OTX Solid Phase Extraction (SPE)
To ensure recovery and reproducibility for oligo extraction from tissue, it is imperative that an effective sample pretreatment strategy is used. This includes a digestion with Proteinase K and tissue pulverization. Homogenate may then be treated as any other sample matrix, and extraction of the oligonucleotide may then be performed using the Clarity OTX solid phase extraction platform.
Extraction of 2’-MOE Phosphorothioate from Tissue Using Clarity OTX Solid Phase Extraction (SPE)
To ensure recovery and reproducibility for oligo extraction from tissue, it is imperative that an effective sample pretreatment strategy is used. This includes a digestion with Proteinase K and tissue pulverization. Homogenate may then be treated as any other sample matrix, and extraction of the oligonucleotide may then be performed using the Clarity OTX solid phase extraction platform.
Document Type:
Technical Notes
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Techniques:
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Separation Modes:
Reversed Phase, Solid Phase Extraction
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