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Rapid Analysis of Genotoxic Nitrosamines by HPLC-MS/MS
Potential genotoxic impurities (PGIs) have been a subject of concern for the pharmaceutical industry for the last decade. PGIs are small, reactive molecules, which can react with DNA/RNA causing damage and the potential risk of cancer. These molecules can, however, be required for successful chemical synthesis and it is not always possible to eliminate them from synthetic pathways
Rapid Analysis of Genotoxic Nitrosamines by HPLC-MS/MS
Potential genotoxic impurities (PGIs) have been a subject of concern for the pharmaceutical industry for the last decade. PGIs are small, reactive molecules, which can react with DNA/RNA causing damage and the potential risk of cancer. These molecules can, however, be required for successful chemical synthesis and it is not always possible to eliminate them from synthetic pathways
Document Type:
Technical Notes
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Separation Modes:
Reversed Phase
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