Documents
Determining Critical Quality Attributes for Adeno-Associated Virus Analysis
This poster introduces a novel prototype size exclusion chromatography (SEC) column designed to enhance the analytical capabilities crucial for the development and analysis of Adeno-Associated Viruses (AAVs) in gene and cell therapy. Limitations of various non-LC analytical methods are reviewed with highlights given to complementary and/or orthogonal techniques during early development phases. The analytical potential of LC methods, particularly SEC, is emphasized, focusing on Critical Quality-Attributes outlined by USP guidelines. Herein, we review how a prototype SEC column addresses specific challenges related to the comprehensive analysis of AAVs, covering aspects such as capsid purity, aggregation, free DNA, and genome titer.
Determining Critical Quality Attributes for Adeno-Associated Virus Analysis
This poster introduces a novel prototype size exclusion chromatography (SEC) column designed to enhance the analytical capabilities crucial for the development and analysis of Adeno-Associated Viruses (AAVs) in gene and cell therapy. Limitations of various non-LC analytical methods are reviewed with highlights given to complementary and/or orthogonal techniques during early development phases. The analytical potential of LC methods, particularly SEC, is emphasized, focusing on Critical Quality-Attributes outlined by USP guidelines. Herein, we review how a prototype SEC column addresses specific challenges related to the comprehensive analysis of AAVs, covering aspects such as capsid purity, aggregation, free DNA, and genome titer.
Document Type:
Poster
Target Industries:
Brands:
Separation Modes:
Size Exclusion
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