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N-Nitroso Furosemide analysis using a SCIEX 5500+ system
Furosemide is used to treat fluid retention caused by heart failure, liver scarring or kidney disease. It is also used in the treatment of high blood pressure. Furosemide works by reducing the amount of sodium reabsorption in the kidneys and can also result in the lowering of other plasma electrolytes such as potassium. As with any routinely prescribed medication, it is important to ensure purity of the active pharmaceutical ingredient together with any formulated product. As Furosemide is a secondary amine, there is the potential that an NDSRI (nitrosamine drug substance related impurity) can be formed. Such NDSRIs have the potential to be carcinogenic and therefore the presence of NDSRIs must be monitored. This technical note describes the separation and detection of Furosemide and it’s associated NDSRI.
N-Nitroso Furosemide analysis using a SCIEX 5500+ system
Furosemide is used to treat fluid retention caused by heart failure, liver scarring or kidney disease. It is also used in the treatment of high blood pressure. Furosemide works by reducing the amount of sodium reabsorption in the kidneys and can also result in the lowering of other plasma electrolytes such as potassium. As with any routinely prescribed medication, it is important to ensure purity of the active pharmaceutical ingredient together with any formulated product. As Furosemide is a secondary amine, there is the potential that an NDSRI (nitrosamine drug substance related impurity) can be formed. Such NDSRIs have the potential to be carcinogenic and therefore the presence of NDSRIs must be monitored. This technical note describes the separation and detection of Furosemide and it’s associated NDSRI.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Reversed Phase
Phases:
N-Nitroso Furosemide analysis using a SCIEX 5500+ system
Furosemide is used to treat fluid retention caused by heart failure, liver scarring or kidney disease. It is also used in the treatment of high blood pressure. Furosemide works by reducing the amount of sodium reabsorption in the kidneys and can also result in the lowering of other plasma electrolytes such as potassium. As with any routinely prescribed medication, it is important to ensure purity of the active pharmaceutical ingredient together with any formulated product. As Furosemide is a secondary amine, there is the potential that an NDSRI (nitrosamine drug substance related impurity) can be formed. Such NDSRIs have the potential to be carcinogenic and therefore the presence of NDSRIs must be monitored. This technical note describes the separation and detection of Furosemide and it’s associated NDSRI.
| Target Industries: | Nitrosamine Analysis, Pharmaceutical |
| Techniques: | HPLC, HPLC Reversed Phase |
| Brands: | Kinetex |
| Separation Modes: | Reversed Phase |
| Phases: | Kinetex Biphenyl |
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.