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Alternative Column for USP Monograph-227: 4-Aminophenol in Acetaminophen-Containing Drug Products
Acetaminophen, is a common non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. It is a widely available over-the-counter drug globally, sold under various brand names. In this technical note we demonstrate that both Luna™ Omega PS C18, (5 µm 150 x 4.6 mm) and Kinetex™ EVO C18 (5 µm 150 x 4.6 mm) meet the acceptance criteria for USP -227: 4-Aminophenol in Acetaminophen containing drug products. The USP Chapter specifies the use of an L85 column, which is a mixed-mode phase column. However, in this work, we demonstrate the suitability of using a L1 columns that meet the SST requirements.
Alternative Column for USP Monograph-227: 4-Aminophenol in Acetaminophen-Containing Drug Products
Acetaminophen, is a common non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. It is a widely available over-the-counter drug globally, sold under various brand names. In this technical note we demonstrate that both Luna™ Omega PS C18, (5 µm 150 x 4.6 mm) and Kinetex™ EVO C18 (5 µm 150 x 4.6 mm) meet the acceptance criteria for USP -227: 4-Aminophenol in Acetaminophen containing drug products. The USP Chapter specifies the use of an L85 column, which is a mixed-mode phase column. However, in this work, we demonstrate the suitability of using a L1 columns that meet the SST requirements.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Reversed Phase
Phases:
Alternative Column for USP Monograph-227: 4-Aminophenol in Acetaminophen-Containing Drug Products
Acetaminophen, is a common non-opioid analgesic and antipyretic agent used to treat fever and mild to moderate pain. It is a widely available over-the-counter drug globally, sold under various brand names. In this technical note we demonstrate that both Luna™ Omega PS C18, (5 µm 150 x 4.6 mm) and Kinetex™ EVO C18 (5 µm 150 x 4.6 mm) meet the acceptance criteria for USP -227: 4-Aminophenol in Acetaminophen containing drug products. The USP Chapter specifies the use of an L85 column, which is a mixed-mode phase column. However, in this work, we demonstrate the suitability of using a L1 columns that meet the SST requirements.
| Target Industries: | Pharmaceutical |
| Techniques: | HPLC, HPLC Reversed Phase |
| Brands: | Kinetex, Luna Omega |
| Separation Modes: | Reversed Phase |
| Phases: | Kinetex EVO C18, Luna Omega PS C18 |
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.