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Modernization of USP Method – Nifedipine Assay and Organic Impurities (TN-1399)
Nifedipine is classified as a calcium channel blocker, primarily utilized for the treatment of hypertension (high blood pressure) and angina (chest pain). It may be administered either as a standalone treatment or in conjunction with other medications to effectively manage blood pressure levels. This study demonstrates the successful separation of Nifedipine from its organic impurities and assay in accordance with the USP Monograph.
Additionally, as part of the effort to modernize the chromatographic method, enhancements have been made to improve performance and reduce analysis time by employing smaller particles and shorter columns, all while adhering to the permissible adjustments outlined in the USP General Chapter <621>.
Modernization of USP Method – Nifedipine Assay and Organic Impurities (TN-1399)
Nifedipine is classified as a calcium channel blocker, primarily utilized for the treatment of hypertension (high blood pressure) and angina (chest pain). It may be administered either as a standalone treatment or in conjunction with other medications to effectively manage blood pressure levels. This study demonstrates the successful separation of Nifedipine from its organic impurities and assay in accordance with the USP Monograph.
Additionally, as part of the effort to modernize the chromatographic method, enhancements have been made to improve performance and reduce analysis time by employing smaller particles and shorter columns, all while adhering to the permissible adjustments outlined in the USP General Chapter <621>.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Reversed Phase
Phases:
Modernization of USP Method – Nifedipine Assay and Organic Impurities (TN-1399)
Nifedipine is classified as a calcium channel blocker, primarily utilized for the treatment of hypertension (high blood pressure) and angina (chest pain). It may be administered either as a standalone treatment or in conjunction with other medications to effectively manage blood pressure levels. This study demonstrates the successful separation of Nifedipine from its organic impurities and assay in accordance with the USP Monograph.
Additionally, as part of the effort to modernize the chromatographic method, enhancements have been made to improve performance and reduce analysis time by employing smaller particles and shorter columns, all while adhering to the permissible adjustments outlined in the USP General Chapter <621>.
| Target Industries: | Pharmaceutical |
| Techniques: | HPLC, HPLC Reversed Phase |
| Brands: | Kinetex, Luna HPLC Columns |
| Separation Modes: | Reversed Phase |
| Phases: | Kinetex C18, Luna C18(2) |
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.