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What is Sample Preparation Extraction?

Sample preparation, often referred to as sample prep, is a crucial step in analytical workflows that allows scientists to obtain precise and dependable results. It involves a series of techniques aimed at extracting, purifying, and concentrating target analytes from complex matrices. Whether you are analyzing environmental, food and beverage, or pharmaceutical samples, proper sample preparation is key to ensuring the efficiency and accuracy of your analysis.
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Fundamental Tips

Solid Phase Extraction (SPE) Method Development: A Practical Overview article

Generic SPE Method by Retention Mechanism article

How is normal phase SPE different from reversed phase SPE? How do I decide which one to use? article

How much sample can I load onto my SPE device? Is it linked to the concentration of my analyte of interest? article

VIDEO Are you using the right SPE wash step?video

What is the Matrix Effect? article

Why Is It Necessary to Dry the SPE Sorbent Before Elution? article

NEW: VIDEO What is magnetic bead-based protein purification? video

Application

Considerations when working with solid samples and SPE article

Sample Pre-treatment Procedures for Bioanalytical Samples article

Peptide Mapping Sample Prep - Good Practices for Tryptic Digests article

Sample prep for N-linked Glycans - The use of a sample prep plate for cleaning up N-linked glycans cleaved from glycoproteins article

Sample Preparation for Oligonucleotides article

All My Analytes are Neutrals, but Contaminants are Acids or Amines. What is the Best Way to Concentrate and Clean Up my Analytes of Interest? article

Why Remove Phospholipids From a Sample? article

Video How to improve my oligonucleotide conjugate recovery with Clarity OTX Pro video

Troubleshooting Tips

Over-Drying of Silica-Based SPE Cartridges Can Lead to Poor Sample Recovery article

Troubleshooting SPE article

I am getting low recovery in my SPE method, how do I fix the problem? article

VIDEO My recovery is lower than expected after my SPE method. Why and how can I fix it? video

Why are my recoveries greater than 100%? article

VIDEO My Sample Won’t Flow Through My SPE Cartridge, Why Is This Happening? video

SPE Troubleshooting - Extra Peak article

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