Understanding Core-Shell Technology
What is Core-Shell?
Core-shell represents a groundbreaking technique that has transformed chromatography. This advanced technology employs particles with a solid core enveloped by a porous shell, resulting in enhanced separation efficiency allowing for increased sample throughput or higher resolution separation of complex mixtures.
Core-shell technology is a state-of-the-art approach to producing high performance stationary phases for U/HPLC. It involves creating structures where a solid silica core is encased by a thin porous shell layer. This innovative design presents numerous advantages over traditional particle structures, making it highly valuable in many applications.
The formation of core-shell structures occurs through a process known as shell deposition. In this process, a precursor material is meticulously coated onto the solid core particles' surface. The precursor material then transforms, forming a thin, uniform shell layer around the core. The shell layer's thickness can be precisely controlled, allowing for customization based on specific needs.
Core-shell technology offers several significant benefits. One major advantage is enhanced efficiency. The unique structure of core-shell particles allows for superior separation and improved analytical performance. The shell layer's controlled porosity provides faster analysis times, and better resolution.
Moreover, core-shell technology enhances sensitivity. The shell layer minimises diffusion of the analyte bands making the peaks narrower and therefore taller. This leads to more accurate and reliable analytical results.
Phenomenex leads in core-shell technology, offering a range of innovative products tailored to meet the diverse needs of scientists and researchers. Our core-shell particles deliver outstanding performance, providing increased efficiency and sensitivity for various applications.
Benefits of Core-Shell
The benefits of core-shell materials in analytical techniques are numerous. Their limited diffusion pathway and tailored properties enable enhanced sensitivity and resolution in various analytical methods. For example, core-shell particles used as stationary phases in liquid chromatography exhibit improved separation efficiency, resulting in sharper peaks and better resolution of analytes. This allows for more accurate quantification and identification of compounds in complex samples. Additionally, the unique properties of core-shell materials provide improved mass transfer, contribute to faster analysis times and higher sample throughput.
Applications of Core-Shell Technology
Core-shell technology represents a significant advancement in analytical chemistry and due to these advantages has found applications across multiple industries. Pharmaceutical, food safety, clinical research, environmental, regulatory and research labs all benefit from implementing core-shell technology into their laboratories. Some o of popular core-shell applications.
Phenomenex Core-Shell Products
Phenomenex proudly offers a wide range of cutting-edge core-shell products that have revolutionized chromatography. Our core-shell columns deliver unmatched performance and efficiency, aiding scientists and researchers in achieving superior analytical results.
Kinetex Core-Shell Columns offer a wide variety of lc column particle sizes, stationary phases and dimensions. The particle morphology results in less band broadening for all four sources of UHPLC band broadening compared to fully porous particles and thus delivers extremely high efficiencies. Phenomenex designs, manufactures, and sells its very own silica and organo-silica core-shell particles.
Core-shell medias are also available in Aeris Core-Shell Technology for Proteins and Peptides and Biozen Biologics LC Columns which has specific core-shell phases combined with BioInert hardware to futher imrpove sensitivity and chromatographic performance.
Furthermore, Phenomenex core-shell columns are compatible with various sample matrices and mobile phases, making them versatile for different analytical methods. Whether you are analyzing small molecules, peptides, proteins, or complex mixtures, our core-shell products provide reliable and reproducible results.
By choosing Phenomenex core-shell columns, you can significantly enhance your analytical performance, saving time and resources while achieving superior separation and detection. Discover the potential of our core-shell technology and unlock new possibilities in your chromatographic analyses.
