Clarity OTX Pro
Standardized Extraction for Complex Therapeutic Oligonucleotides
Clarity OTX Pro is designed to address the inefficiencies in therapeutic oligonucleotide extraction for bioanalysis. With a DNA/RNA-ase free formulation, user-friendly lysis-loading buffer, and a wide range of sorbent bed masses, Clarity OTX Pro enables reliable and reproducible LC/MS analysis of complex oligonucleotides and oligo-conjugates. The inclusion of readily available Proteinase K further simplifies workflows and enhances consistency.
Reliable, Reproducible, and Ready for Method Transfer
- Engineered for complex oligonucleotide therapeutics and novel conjugates
- Day-to-day reproducibility with < 10%
- Well-characterized method development ranges for standardized protocols
Extraction and Collection Plates
- 8E-S103-AGA
- 8E-S103-CGA
- 8E-S103-DGA
- 8E-S103-EGA
- 8M-S103-4GA
- AH0-7194
Kits and Reagents
- AL0-8500
- AL0-8501
- AL0-8502
- KS0-9540
- KS0-9541
Extraction Tubes
- 8B-S103-EBJ
- 8B-S103-HCH
- 8E-S103-AGA
Manifolds and Sealing Mats
- AH0-7195
- AH0-8950
- VM24
Overview
Explore the Clarity OTX Pro demo walkthrough for expert tips and best practices.
Linearity and Accuracy Range of Over 100-fold Dynamic Range
Extracted Standards (Std): Area vs. Concentration 1-900 ng/mL load; R2 = 0.99
(ng/mL)
(ng/mL)
Full Range TIC 1-900 ng/mL load
High Recovery at Low Concentrations With Minimal Optimization
GalNAc-conjugated siRNA extracted from rat plasma using Clarity OTX Pro.
Extract 1
Post-Extract Spike EIC (2 ng/mL load) 97% Recovery
Extract 2
Post-Extract Spike EIC (2 ng/mL load) 106% Recovery
