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• Lux® Polysaccharide-Based Chiral SFC/HPLC Columns
Complementary selectivities that allow you to screen for the most effective chiral separation under SFC conditions
• SecurityGuard® Universal Guard Cartridge System
Extend the lifetime of your chiral SFC column
HPLC Animation Video
SFC Basics Overview
HPLC Column Web Tool
Normal Phase is used to separate hydrophobic compounds and matrices that are retained too strongly by reversed phase and have minimal solubility in aqueous mobile phases.
Chiral supercritical fluid chromatography can be used to efficiently separate and purify enantiomers. SFC is similar to normal phase chromatography but instead incorporates pressurized carbon dioxide as the main component of the mobile phase. Since supercritical fluids are close to the critical point, small changes in temperature and pressure will cause large changes in density. These changes can have dramatic effects in selectivity and separation for chiral compounds.
Simplified Chiral HPLC/SFC Column Screening Strategies
Recommended instructions for the care and use of your Lux analytical column under SFC conditions (internal ID ≤ 4.6 mm)
Fun facts and statistics of our SFC column portfolio and other SFC services
• Luna® HILIC
Novel cross-linked diol phase
Unique ether-linked phenyl phase
Versatile PFP (pentafluorophenyl) phase
• Luna Silica
Ultra-pure silica phase
• Luna NH2
Robust amino phase
• Luna CN
Stable cyano phase
Supercritical fluid chromatography (SFC) is predominately used for low to moderate molecular weight compounds and can provide significant advantages in selectivity since mobile phase density directly impacts the affinity of the mobile phase for target analytes.
We offer a full line of unique selectivities designed to offer very different interactions with analytes under supercritical fluid chromatography (SFC) conditions.
Achiral Stationary Phase Selectivity under Supercritical Fluid Chromatography (SFC) Conditions
• Axia ™ Packed Preparative SFC/HPLC Columns
Axial compressed preparative columns are guaranteed to offer better column lifetime and improved overall performance
Prep Calculator Web Tool
Preparative supercritical fluid chromatography (SFC) offers significant advantages in sample recovery, faster and easier fraction collection due to reduced sample volume, and cost reduction in the use of organic solvents. Preparative SFC is becoming more popular for chiral purification as well as achiral small molecule purification.
We provide a full suite of chiral and achiral axial-packed preparative SFC columns available in 21.2 mm, 30 mm and 50 mm IDs for small to medium scale preparative supercritical fluid chromatography.
Direct Comparison of HPLC and SFC for the Milligram to Gram Scale Purification of Enantiomers
Fun facts of our PREP packed column, bulk media portfolio, and other services
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