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Strata-X

Simplified Solid Phase Extraction Solutions

Strata-X Polymeric SPE Information


Capitalize on Cleanliness without Sacrificing Recovery

With Strata™-X polymeric SPE sorbents the guesswork that leads to lengthy method development is eliminated. Unique selectivities have been developed to cover a diverse spectrum of analytes, and simplify the method development process for fast and efficient sample preparation.

  • Tightly retain analytes by several different sorbent-analyte interactions
  • Remove unwanted contaminants including phospholipids for superior chromatography
  • Easily cleanup large volume or viscous samples as well as target analytes that exceed 10 kDa
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X, Polymeric Reversed Phase Phase Detail


Sorbent TypePolymer-based
Surface Area (sq. m/g)800
pKaN/A
Target AnalytesNeutral and aromatics
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X, Polymeric Reversed Phase Phase Information


A reversed phase functionalized polymeric sorbent that gives strong retention of neutral, acidic, or basic compounds under aggressive, high organic wash conditions.  This sorbent relies on 3 mechanisms of retention: pi-pi bonding, hydrogen bonding (dipole-dipole interactions), and hydrophobic interaction.

PhaseSorbent TypeSurface Area (sq. m/g)pKaTarget Analytes
X, Drug B, Strong Cation Mixed Mode Polymer-based800ProprietaryBasic drugs of abuse
X, Drug N, Polymeric Reversed Phase 520N/A
X, Polymeric Reversed Phase Polymer-based800N/ANeutral and aromatics
X, Polymeric Reversed Phase Polymer-based800N/ANeutral and aromatics
X-A, Strong Anion Mixed Mode Polymer-based800~14Weakly acidic compounds
X-AW, Weak Anion Mixed Mode Polymer-based800~9Acidic compounds (i.e.) strong acids
X-C, Strong Cation Mixed Mode Polymer-based800~0Weakly basic compounds
X-C, Strong Cation Mixed Mode Polymer-based800~0Weakly basic compounds
X-CW, Weak Cation Mixed Mode Polymer-based800~4.5Basic compounds, particularly strong bases
X-CW, Weak Cation Mixed Mode Polymer-based800~4.5Basic compounds, particularly strong bases
XL, Polymeric Reversed Phase Polymer-based520N/ANeutrals, aromatics present in viscous samples
XL-A, Strong Anion Mixed Mode Polymer-based520~14Weakly acidic compounds present in viscous samples
XL-AW, Weak Anion Mixed Mode Polymer-based520~9Acidic compounds (i.e. strong acids) present in viscous samples
XL-C, Strong Cation Mixed Mode Polymer-based520~0Weakly basic compounds, present in large volume or viscous samples
XL-CW, Weak Cation Mixed Mode Polymer-based520~4.5Basic compounds (i.e.strong bases) present in viscous samples
Document Type:
Document Type Title
Technical Notes Drugs of Abuse Panel from Urine by GC/MS and LC/MS (TN-0041) Add to My Documents
Other Clinical Research Solutions Guide Add to My Documents
Technical Notes Endothalls in Water by EPA Method 548.1 using SPE and GC/MS (TN-0067) Add to My Documents
Technical Notes Hormones from Drinking Water by LC/MS/MS (TN-1163) Add to My Documents
Technical Notes Improved Recoveries using SPE vs. Liquid-Liquid Extraction (TN-0044) Add to My Documents
Brochures Meet Your SPE Support Team Add to My Documents
Other Pain Panel/Pain Management Drugs Applications Guide Add to My Documents
Webinar How to Determine the Best Sample Preparation Technique for your Unique Samples Add to My Documents
Technical Notes A Simplified Approach to Sample Preparation (TN-013) Add to My Documents
Brochures Strata-X Sorbent Selection Guide Add to My Documents
Webinar Solid Phase Extraction Basics Webinar Add to My Documents
Brochures Strata-X Mini Brochure Add to My Documents
Brochures Strata-X vs. Waters Oasis Add to My Documents
Brochures Strata-X-Drug, SPE Sorbents Designed for Drugs of Abuse Analysis Add to My Documents
Brochures Strata-X-Drug B for Drugs of Abuse Add to My Documents
Brochures Quick and Simple Cleanup for Medicinal Chemistry Add to My Documents
Technical Notes Benzodiazepines from Urine and Plasma by LC/MS/MS (TN-0054) Add to My Documents
Other Vitamin Testing Applications Guide Add to My Documents
Technical Notes 41 Pain Management Drugs from Urine by LC/MS/MS (TN-0053) Add to My Documents
Technical Notes A Simple Approach to Automated SPE (TN-014) Add to My Documents
Other A Simple, Rapid Method for teh Analysis of Ethephon from Ketchup using Solid Phase Extraction and LCMSMS Add to My Documents
Technical Notes Acidic Drugs from Plasma by HPLC/UV (TN-0036) Add to My Documents
Technical Notes Aggressive Cleanup of Sulfa Drugs (TN-010) Add to My Documents
Other Automated Extraction of Benzodiazepines from Urine and Plasma by LC/MS/MS (Poster) Add to My Documents
Technical Notes Bisphenol A from Water by HPLC/FLD (TN-0040) Add to My Documents
Technical Notes Chiral Separation of Synthetic Cannabinoid Metabolites (TN-1167) Add to My Documents
Technical Notes Chloramphenicol from Shrimp by LC/MS/MS (TN-1081) Add to My Documents
Technical Notes Chloramphenicol from Various Food Matrices by LC/MS/MS (TN-1120) Add to My Documents
Other Corisol, Cortisone, Prednisolone, and Prednisone from Urine by SPE and LC/MS/MS Add to My Documents
Technical Notes Basic Drugs from Biological Matrices (TN-008) Add to My Documents
Technical Notes Evaluation of Newer Technologies for the LC/MS/MS Analysis of Amphetamines (TN-1096) Add to My Documents
Technical Notes Haloacetic Acids from Water by GC/ECD (TN-0039) Add to My Documents
Technical Notes Cleanup of Polar Acids (TN-0037) Add to My Documents
Technical Notes Sulfonamides from Honey by LC/MS/MS (TN-0012) Add to My Documents
Technical Notes Hop Acids from Beer by HPLC/UV (TN-1085) Add to My Documents
Supporting Docs How to Improve Sample Preparation Accuracy, Reproducibility, and Lab-to-Lab Variation with Automation Add to My Documents
Technical Notes Barbiturates from Urine by LC/MS/MS (TN-0045) Add to My Documents
Technical Notes LC/MS/MS Analysis of Immunosuppressants from Whole Blood (TN-1169) Add to My Documents
Technical Notes Metanephrine and Normetanephrine from Plasma by LC/MS/MS (TN-0018) Add to My Documents
Technical Notes Metronidazole from Foaming Facial Cleanser by LC/MS/MS (TN-0049) Add to My Documents
Technical Notes Nicotine, Cotinine, 3-Hydroxycotinine, Nornicotine and Anabasine in Human Urine by LC/MS/MS (TN-1161) Add to My Documents
Technical Notes Oil Dispersants (COREXIT 9527 and 9500) by GC/MS and LC/MS/MS (TN-2046) Add to My Documents
Technical Notes Optimization of Wash/Elution Conditions for Automated SPE of Testosterone from Plasma (TN-0017) Add to My Documents
Technical Notes Pain Management and Illicit Drugs from Oral Fluids by LC/MS/MS (TN-0068) Add to My Documents
Technical Notes Palladium Catalyst Removal from a Suzuki Reaction (TN-0046) Add to My Documents
Technical Notes Digoxin and Digitoxin in Plasma by LC/MS/MS (TN-1099) Add to My Documents
Technical Notes Sudan Dye Contaminants in Spices by HPLC/UV (TN-015) Add to My Documents
Technical Notes Steroids from Urine and Plasma by LC/MS/MS (TN-1096) Add to My Documents
Technical Notes Strata-X General Method for the Extraction of Neutral Compounds (TN-0023) Add to My Documents
Technical Notes Strata-X-A General Method for the Extraction of Weak Acids (TN-0035) Add to My Documents
Technical Notes Strata-X-AW General Method for the Extracion of Weak Acids (TN-0025) Add to My Documents
Technical Notes Strata-X-AW General Method for the Extraction of Any Acid (TN-0024) Add to My Documents
Technical Notes Strata-X-AW General Method for the Extraction of Weak Acids Add to My Documents
Technical Notes Strata-X-C General Method for the Extraction of Weak Bases (TN-0026) Add to My Documents
Technical Notes Strata-X-CW General Method for the Extraction of Any Base (TN-0027) Add to My Documents
Technical Notes Strata-X-CW General Method for the Extraction of Weak Bases (TN-0028) Add to My Documents
Technical Notes Strata-XL General Method for the Extraction of Neutral Compounds (TN-0029) Add to My Documents
Technical Notes Strata-XL-A General Method for the Extraction of Weak Acids (TN-0038) Add to My Documents
Technical Notes Strata-XL-AW General Method for the Extraction of Any Acid (TN-0030) Add to My Documents
Technical Notes Strata-XL-AW General Method for the Extraction of Weak Acids (TN-0031) Add to My Documents
Technical Notes Strata-XL-C General Method for the Extraction of Weak Bases (TN-0032) Add to My Documents
Technical Notes Strata-XL-CW General Method for the Extraction of Any Base (TN-0033) Add to My Documents
Technical Notes Strata-XL-CW General Method for the Extraction of Weak Bases (TN-0034) Add to My Documents
Technical Notes Synthetic Cannabinoids and Their Metabolites from Urine by LC/MS (TN-1154) Add to My Documents
Technical Notes Testosterone from Human Serum by LC/MS/MS (TN-1103) Add to My Documents
Technical Notes Tricyclic Antidepressants from Plasma by LC/MS/MS (TN-0056) Add to My Documents
Technical Notes Ultra-Selective and Fast Analysis of Phenylbutazone in Ground Meat using Strata-X-A (TN-0059) Add to My Documents
Technical Notes Testosterone (Total) from Human Serum by UHPLC/MS/MS (TN-1103) Add to My Documents
Technical Notes Bianalytical Sample Pre-treatment (TN-0064) Add to My Documents
Supporting Docs Declaration of Conformity Add to My Documents
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