Biozen dSEC-1
High-Resolution Aggregate Analysis for Peptide Therapeutics
Biozen dSEC-1 columns are engineered to meet the growing demand for aggregate analysis in peptide therapeutics and mid-sized biologics. Packed with 90 Å small pore silica and featuring inert diol-based surface chemistry, dSEC-1 delivers enhanced resolution for low and high molecular weight peptide aggregates. Its robust design ensures reproducibility and compatibility with advanced workflows like SEC-MS and SEC-MALS.
Robust Performance for Peptide Aggregate Analysis
- High resolution for low/high MW peptide aggregates (1–50 kDa)
- Reproducible, and fast analysis with extended column lifetime
- Improved peak asymmetry by up to 40%
Order
Aggregate and Monomer Separation in Liraglutide Formulations
- Baseline resolution of monomer and two aggregates achieved in under 10 minutes
- Exceptional reproducibility with retention time RSD ≤ 0.08% and peak area RSD ≤ 0.01%
- Clear detection at low levels with S/N ratios of 13, 75, and 10,917 for aggregates and monomer
High-Resolution SEC for siRNA Sequence Differentiation
- Clear resolution achieved between closely related species differing by just three bases
- Robust SEC performance enables confident ID and quantification of CholTEG-conjugated siRNA
- Ideal for therapeutic oligo workflows requiring high resolution and reproducibility
Separation of Sense/Antisense Strands in CholTEG-Conjugated siRNA
- Excellent resolution of duplex, sense (5900 Da), and antisense (6900 Da) strands achieved
- Supports formulation and stability studies through clear resolution of structurally related species
