Biozen Glycan
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Overview
Minimize your priming with our BioTi™ Biocompatible hardware
Sample:
- γ-Globulin, 5 mg/mL
- Ovalbumin, 1 mg/mL
Intact and Fragment Analysis
Impurity profiling and characterization of intact biologic fragments is a challenging undertaking because of the need to identify very small differences between variants. Both bioZen Intact columns contain skillfully manufactured large pore core-shell particles that provide narrower, taller peaks in conjunction with higher resolution between the target HC/LC, Fc/Fab, or isoforms
Intact Trastuzumab at 70, 80, and 90°C
Samples:
- Trastuzumab
Infliximab F(ab)2
Sample:
- Infliximab F(ab)2
Cetuximab
Sample:
- Cetuximab
Drug Antibody Ratio (DAR)
With a direct effect on efficacy and safety, conjugation for each ADC must be well understood. The bioZen Intact XB-C8 provides an excellent vehicle for determining drug load distribution and DAR for ADCs. Its large pore size allows intact ADCs to interact with a moderately retentive stationary phase while the core-shell particle supplies increased efficiency to deliver the required resolution between ADC species with differing drug loads.
Herceptin—vcMMAE using bioZen 3.6 µm Intact XB-C8
Herceptin—mcMMAF using bioZen 3.6 µm Intact XB-C8
scFc and F(ab’)2
Our bioZen Intact XB-C8 column shows improved peak shape and scFc detection.
Comparative separations may not be representative of all applications.
Conditions for all columns:
Agilent 3.5 μm AdvanceBio RP-mAb SB-C8
Sample:
Cetuximab
Heavy Chain, Light Chain Analysis
Observe excellent separation of heavy chain variants using the bioZen™ Intact XB-C8 column in your mAb intact fragment analysis.
Conditions for all columns:
Agilent 3.5 μm AdvanceBio RP-mAb SB-C8
Sample:
Cetuximab
Distilled Alcohol Standard by Neat Injection on GC-FID
Comparative separations may not be representative of all applications.
Conditions for all columns:
Agilent 3.5 μm AdvanceBio RP-mAb SB-C8
Sample:
- Rituximab