Strata-XL-CW SPE Products

Large Particle Weak Cation Mixed-Mode Solid Phase Extraction (SPE)

A weak cation-exchange functionalized polymeric sorbent that allows for complete retention of basic compounds with a pK_a greater than 8, including quaternary amines, making 100% organic wash conditions possible. A 100% organic wash ensures that the maximum amount of interferences are removed from the target compound. The large particle format is ideal for processing large volumes or viscous samples.

Brand Strata-X
Recommended Use Extraction of basic compounds, particularly strong bases, present in viscous samples

How It Works
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3 Mechanisms of Retention

Weak Cation-Exchange

π-π Bonding

Hydrophobic Interaction

Available Formats

96-Well Plates

1, 3, and 6 mL Tubes

Giga™ Tubes (12-150 mL Tubes)

Starting Method

For Bases with pK_a > 8

Column: 1 mL Methanol
Equilibrate: 1 mL Water, pH 6-7
Load: Diluted Sample pH 6-7
Wash 1: 1 mL Water, pH 6-7
Wash 2: 1 mL Methanol (collect this fraction to analyze Neutrals/Acids)
Elute Any Acids: 2x 500 µL 5 % Formic Acid in Methanol
Elute Weak Acids: 2x 500 µL 5 % NH₄OH in Methanol

Based on 30 mg/1 mL sorbent mass. The above is a convenient starting point for SPE method development, further optimization may be required to tailor the method for your specific extraction needs.