For security purposes
FOR SECURITY PURPOSES - because Internet Explorer is no longer supported by Microsoft, we suggest that you interact with our secure site through one of our supported browsers - Google Chrome, Firefox, or MS Edge. If you continue to use this website with Internet Explorer you do so at your own risk and you may encounter problems.
  • Filter by:
  • Refine Search
  • Technique
    expand_less
  • Brand
    expand_more
  • Phase
    expand_more
  • Industry
    expand_more
  • Separation Mode
    expand_more
  • Page Type
    expand_more
  • Format
    expand_more
  • Particle Size (µm)
    expand_more
  • Pore Size (Å)
    expand_more
  • Length (mm)
    expand_more
  • Internal Diameter (mm)
    expand_more
  • Length (m)
    expand_more
  • Composition
    expand_more
  • Film Thickness (µm)
    expand_more
  • Particle Size Range
    expand_more
  • Sorbent Mass (mg) / Volume (mL)
    expand_more
  • Sorbent Mass
    expand_more
  • Accessory Type
    expand_more
8019 Results for ""share
descriptionTechnical Notes
USP Alosetron Hydrochloride Assay and Organic Impurities on Gemini 3 µm C18 (AN-1010)
This application note for the LC-UV assay and organic impurities for Alosetron hydrochloride is based on the USP monograph, which was validated using the Gemini 3 µm C18 column for both the assay (isocratic) and organic impurities (gradient).
descriptionTechnical Notes
USP Alosetron Tablets Assay and Organic Impurities on Gemini 3 µm C18 (AN-1011)
Alosetron hydrochloride, a potent and selective antagonist of the serotonin 5-HT3 receptor, is the active pharmaceutical ingredient in Lotronex tablets, and there are several generic versions of Alosetron tablets available on the market. This application note for the LC-UV assay and organic impurities for Alosetron tablets is based on the official USP monograph, which was validated using the Gemini 3 µm C18 column for both the assay (isocratic) and organic impurities (gradient).
descriptionBrochures
The Alternative Matrix Guide: Hair and Oral Fluid Method Development
Both hair and oral fluid are difficult matrices to work with due to the sample preparation and chromatography challenges. Discover our method development solutions for these alternative matrices and how to solve these problems in your own lab.
descriptionTechnical Notes
USP Vardenafil Hydrochloride Assay and Organic Impurities on Gemini 5 µm C18 and Gemini 5 µm NX-C18 (AN-1014)
This application note for the LC-UV assay and organic impurities for Vardenafil hydrochloride drug substance is based on the official USP monograph which calls for an L1 (C18) 5 µm, 250 x 3.0 mm column under gradient conditions for both assay and organic impurities. The mobile phase, standard solution, and system suitability solution for the assay and organic impurities were prepared in accordance with the USP monograph, using the USP Vardenafil hydrochloride reference standard and Vardenafil hydrochloride system suitability reference standard (containing 99% Vardenafil hydrochloride and 1% 7-Methylvardenafil). Vardenafil hydrochloride is a PDE-5 inhibitor and is the generic version of the brand name drug Levitra.
descriptionGuide
Cannabis Testing Guide (LC/GC/SP)
The latest applications and resources for testing potency, pesticides, mycotoxins, terpenes, and residual solvents.
descriptionTechnical Notes
Performance of Surface Modified Luna Omega and Kinetex PS Columns for the Separation of Tricyclic Antidepressants
Performance of Surface Modified Luna Omega and Kinetex PS Columns for the Separation of Tricyclic Antidepressants
descriptionTechnical Notes
An Analytical Method Using the Zebron™ ZB-1 GC Column to Highlight the Opportunity to Resolve the Volatile Polar Sulfur Compounds in Petroleum Fuel
An Analytical Method Using the Zebron™ ZB-1 GC Column to Highlight the Opportunity to Resolve the Volatile Polar Sulfur Compounds in Petroleum Fuel
descriptionTechnical Notes
Faster Analysis of 18 Phthalates by GC-MS using Zebron ZB-PAH-CT GC Column
Faster Analysis of 18 Phthalates by GC-MS using Zebron ZB-PAH-CT GC Column
descriptionBrochures
Luna Omega C18 Application eBook
One of the world's leading HPLC brands, now enhanced for incredible LC performance! Luna Omega 1.6µm, 3µm, and 5µm C18 HPLC/UHPLC columns culminate 20 years of technological advancements and innovation.
descriptionTechnical Notes
Reference Analysis of Loratadine from an Oral Solution Using a Kinetex Biphenyl HPLC/UHPLC Column
Loratadine is an antihistamine that can be administered through an oral solution. Because of the aromatic nature of the compound, we investigated a reversed phase method that leveraged the Kinetex 5 µm Biphenyl column. This column was selected because of its relative increased polar retention and aromatic selectivity
descriptionTechnical Notes
Successful Separation of Cannabidiol Enantiomers by LC-UV Analysis using Lux Amylose Chiral Columns
Cannabidiol (CBD) is a phytocannabinoid found in Cannabis, and a major focus of both pharmaceutical research and consumer products. CBD formed from within the plant is created by an enzyme-mediated process which exclusively forms the levorotatory isomer, (-)-cannabidiol, as has been confirmed by optical rotation and NMR analysis of plant extracted and purified material. The first synthetic approach to cannabinoids was based on the use of commercially available, chiral starting materials. This approach is still used in many pharmaceutical synthetic processes this day. For the development of plant-based cannabinoid products, having the ability to verify enantiomeric purity would be an excellent opportunity for quality verification of their products.
descriptionGuide
GC Troubleshooting Guide
The complete guide to GC troubleshooting with hints, tips, and tricks for chromatographic remedies.
descriptionTechnical Notes
Determination of Pantothenic Acid (Vitamin B5) in Human Serum by LC-MS/MS using a Luna Omega Polar C18 column
In this application note, we describe a simplified extraction method of Vitamin B5 from human serum followed by an LC-MS/MS method using a Luna Omega 3 µm Polar C18 column.
descriptionGuide
Choosing the Right UHPLC Column for Intact Peptide Analysis
This technical note walks through the various considerations that need to be taken into account when performing intact peptide analysis. Several UHPLC columns are compared including a Luna Omega C18 and PS C18 and a Waters ACQUITY BEH C18 column.
descriptionGuide
Choosing the Right UHPLC Column for Peptide Mapping
Analysts are increasingly relying upon LC-MS to perform their peptide and protein digest analyses, and TFA is not often used in conjunction with LC-MS due to its strong signal-suppression properties. Thus, when performing peptide analysis by LC-MS using typical mobile phases such as water/acetonitrile/formic acid, secondary interactions between basic amino acids on the peptide and the underlying silica can lead to broad peaks, peak tailing, and can interfere with optimal resolution between close-eluting peaks. To obtain optimal performance for peptide analysis using either LC-UV or LC-MS, the ideal media should be highly efficient (narrow peaks) and highly inert (minimal peak tailing when using MS-compatible modifiers like formic acid). In addition, a more retentive media is often favorable, particularly for peptide mapping, to maximize retention of small, polar peptide fragments that may not have a high affinity for a typical C18 phase, particularly in the absence of TFA (trifluoroacetic acid). Using this information, Luna Omega PS C18 and C18 were tested alongside a Waters ACQUITY UHPLC column.
descriptionTechnical Notes
LC-MS/MS Separation of Furosemide and its Metabolite Using the Kinetex 2.6 µm Biphenyl, Luna Omega 1.6 µm C18, and Luna Omega 1.6 µm Polar C18 Columns
LC-MS/MS Separation of Furosemide and its Metabolite Using the Kinetex 2.6 µm Biphenyl, Luna Omega 1.6 µm C18, and Luna Omega 1.6 µm Polar C18 Columns
descriptionTechnical Notes
Analysis of Explosives Found in EPA 8330A and 8330B Using a Kinetex 2.6 µm Polar C18 Column
Here we present a single high efficiency separation and analysis of common explosives, typically analyzed by EPA 8330A and 8330B. For such a mixture of related compounds, the Polar C18 stationary phase bonded to a Kinetex core-shell particle was chosen because of its high efficiency separation power alongside dual polar/non-polar selectivity that can greatly help to magnify small differences between similar compounds of interest.
descriptionGuide
Choosing the Right UHPLC Column for Multi-Class LC-MS/MS Screening - Pesticides Panel
This technical note walks through the various considerations that need to be taken into account when performing multi-class screening such as a pesticide panel. Several UHPLC columns are compared including a Luna Omega C18 and Polar C18 and a Waters ACQUITY BEH C18 column.
descriptionGuide
Choosing the Right UHPLC Column for Analyzing Strongly Basic Molecules
This technical note walks through the various considerations that need to be taken into account when analyzing strongly basic molecules. Several UHPLC columns are compared including a Luna Omega PS C18 and a Waters ACQUITY BEH C18 column.
descriptionTechnical Notes
Analysis of EPA 8310 Polynuclear Aromatic Hydrocarbons Using a Kinetex 3.5 µm PAH Column
Kinetex 3.5 µm PAH core-shell columns were developed to offer increased sensitivity and speed for PAH HPLC/UHPLC methods such EPA 8310.
descriptionTechnical Notes
Determination of Volatile Organic Compounds in Environmental Samples as per HJ639 using Zebron ZB-624PLUS GC Column
Determination of Volatile Organic Compounds in Environmental Samples as per HJ639 using Zebron ZB-624PLUS GC Column
descriptionTechnical Notes
Metoprolol Tartrate Ph. Eur Monograph
The Ph. Eur. Monograph 1028 outlines the separation of Metoprolol Tartrate from impurities. This method was studied and improvements were made to provide faster separations within allowable adjustments.
descriptionTechnical Notes
Analysis of Genotoxins (NDMA and NDEA) in Sartan Drugs and Drug Products by GC-MS (TN-2080)
N-Nitrosodimethylamine (NDMA) and N-Nitrosodiethylamine (NDEA) are Class 2A carcinogens that have been found to be present as impurities in several different generic drug substances and drug products used to treat hypertension. Accurate identification and quantification of these impurities is essential to assure quality and safety of the drug substance and drug product. In this technical note we illustrate a headspace GC-MS application that allows for ppb detection limits (LOQ equal to 1.5 ppb for NDMA and 0.9 ppb for NDEA; and LOD equal to 0.4 ppb for NDMA and 0.3 ppb for NDEA).
descriptionBrochures
Yarra GFC/SEC Column Product Guide
Biomolecule characterization and purification at extremely affordable prices
descriptionSupporting Docs
Find Your Accessory Sidekick
You can never have too many accessory sidekicks to help you save your columns, defeat evil contaminated particles, and create less system maintenance downstream. Find your ideal sidekick today!