Phospholipid Removal (PLR)

Phospholipids have been shown to reduce HPLC/UHPLC column lifetime and sensitivity and are also responsible for ion suppression. Phospholipids are present in a majority of bioanalytical samples including whole blood and plasma. With an increasing number of applications being developed from bioanalytical samples, the removal of phospholipids from the sample prior to LC-MS/MS analysis has become an important step for accurate analysis.