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HPLC
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Endrix HPLC Column

Built for Extended Column Durability with Complex Matrices

Endrix is the next evolution of Phenomenex LC column technology, building on Kinetex and Luna Omega to maximize instrument uptime. Its proprietary hardware delivers consistent, reliable performance and supports seamless LC‑MS/MS workflows with minimal sample cleanup—no guard columns required—so labs can run more samples with confidence.

Key benefits:

  • Maximizes column lifetime through proprietary hardware design
  • Reduces replacement frequency and column fouling from complex matrices
  • Decreases cost by minimizing column turnover and eliminating guard columns

Endrix long‑life HPLC columns are available in select sizes and chemistries.

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Overview

Endrix HPLC columns are engineered to withstand the rigors of minimal sample cleanup while delivering long life, high performance, and reproducibility. Applications include, but are not limited to:

Comparison of Injections on a Standard Kinetex Biphenyl vs Endrix Kinetex Biphenyl

In a study evaluating 3 standard Kinetex and 3 Endrix Kinetex columns for a hydrolyzed urine LC-MS/MS toxicology panel, Endrix columns demonstrated extended column lifetime of up to 50%.

Comparison of peak shapes for Endrix Kinetex Biphenyl and standard Kinetex Biphenyl

A. Initial (n=1 injection), B. Mid-life (n=900 or 600 injections), C. End of column life showing loss of resolution and asymmetric peak (n = 1781 and 792 injections)