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    Kinetex XB-C18 Core Shell

    A Unique Core-Shell Selectivity

    Di-isobutyl side chains differentiate this C18 column. Low ligand density and an inactive surface make this column a great hydrogen bond acceptor. This phase will demonstrate improved peak shape and increased retention of acidic compounds.

    • Compatible with all Analytical HPLC/UHPLC Systems*
    • Unique C18 Retention (USP: L1)
    • Improved Selectivity of Acidic compounds

    *Kinetex analytical columns are compatible with all LC system with standard LC column end-fittings threaded in 10-32. Please contact us at Phenomenex.com/chat for any questions and information about fitting compatibility and any other column internal diameters.

    Particle Size
    1.7, 2.6, 3.5, 5
    Recommended Use
    Superior peak shape and enhanced separation of basic compounds under neutral and acidic conditions

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    Select Attributes:

    Internal Diameter (mm)

    2.1

    3

    4.6

    10

    21.2

    30

    50

    Length (mm)

    30

    50

    75

    100

    150

    250

    Particle Size (µm)

    1.7

    3.5

    5

    Pore Size (Å)

    100

    Showing 1-5 of 35 Results
    Part: 00A-4498-ANKinetex 1.7 µm XB-C18 100 Å, LC Column 30 x 2.1 mm, ea
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    $1,154.00 USD (Ea)

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    Part: 00A-4498-Y0Kinetex 1.7 µm XB-C18 100 Å, LC Column 30 x 3 mm, ea
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    $1,154.00 USD (Ea)

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    Part: 00A-4605-ANKinetex 5 µm XB-C18 100 Å, LC Column 30 x 2.1 mm, ea
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    $670.00 USD (Ea)

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    Part: 00B-4498-ANKinetex 1.7 µm XB-C18 100 Å, LC Column 50 x 2.1 mm, ea
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    $1,169.00 USD (Ea)

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    Part: 00B-4498-Y0Kinetex 1.7 µm XB-C18 100 Å, LC Column 50 x 3 mm, ea
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    Overview

    Selectivity for Acidic Compounds

    This unique C18 phase yields increased hydrogen bonding with hydrophobic selectivity‚ resulting in improved peak shape for basic compounds and increased retention of acidic compounds.

    Complementary Core-Shell C18 Phases

    Ultra-high performance columns like Kinetex will give you very narrow peaks, but without the right selectivities you are left with very narrow, overlapping peaks. The phases offered in the Kinetex column line are complementary to one another, so the spectrum of selectivity your separations require is covered.

    C18 Phases (C18 vs. XB-C18)

    19487-19488-image

    Conditions for all columns:

    Dimension:

    		50 x 2.1 mm

    Flow Rate:

    		0.5 mL/min

    Temperature:

    		30 °C

    Detection:

    		UV @ 220 nm (ambient)

    Mobile Phase:

    		A: Water, B: Acetonitrile

    Gradient:Time (min)

    % B

    020
    660
    6.0120
    820

    Samples:

    1. Estriol
    2. Hydrocortisone
    3. Cortisone
    4. Estradiol
    5. Cortisone-21-acetate
    6. 21-Hydroxyprogesterone
    7. Estrone
    8. 17-Hydroxyprogesterone
    9. Deoxycorticosterone acetate

    Manipulate Acidic and Basic Compound Retention

    Find the right phase selectivity for your application by investigating the diverse selectivity availability of the Kinetex Core Shell HPLC and UHPLC columns. Where reliable performance meets unique selectivity.

    Conditions for all columns:

    Dimension:

    		50 x 2.1 mm

    Flow Rate:

    		0.8 mL/min

    Temperature:

    		30 °C

    Detection:

    		UV @ 245 nm (ambient)

    Mobile Phase:

    		A: Water with 0.1% Formic Acid, B: Acetonitrile with 0.1% Formic Acid

    Gradient:Time (min)

    % B

    05
    0.25
    4.295
    4.215
    5.55

    Samples:

    1. Pyridine
    2. Acetaminophen
    3. Pindolol
    4. Quinidine
    5. Sulfathiazole
    6. Acebutolol
    7. Benzyl alcohol
    8. Chlorpheniramine
    9. Phenol
    10. Triprolidine
    11. Nortriptyline
    12. Prednisolone
    13. 3-Methyl, 4-nitrobenzoic acid
    14. 2-Hydroxy, 5-methylbenzaldehyde
    15. Diflunisal
    16. Hexanophenone

    Applications

    Rapid Sample Extraction of Chloroquine, Hydroxychloroquine, and Desethylchloroquine from Serum for LC-MS/MS Analysis
    Rapid Sample Extraction of Chloroquine, Hydroxychloroquine, and Desethylchloroquine from Serum for LC-MS/MS Analysis
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    GC-MS Analysis of PAH, PCB and Terphenyl using a 30 meter Zebron ZB-PAH-EU GC column
    GC-MS Analysis of PAH, PCB and Terphenyl using a 30 meter Zebron ZB-PAH-EU GC column
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    GenX replacement PFOA compound by LC-MS/MS
    GenX replacement PFOA compound by LC-MS/MS
    View Details
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    Documents

    Technical Notes
    Micro-flow Peptide Separations
    Guide
    System Optimization Manual
    Brochures
    roQ QuEChERS Brochure
    Poster
    HPLC/UHPLC Selectivity Poster
    Brochures
    Kinetex Core-Shell Technology Overview
    Brochures
    United States Pharmacopeia (USP) Allowable Adjustments Guide
    Supporting Docs
    Expand Your LC Selectivity Toolbox
    Brochures
    LC Columns For Clinical Research
    Brochures
    Axia- The Ultimate Pre-packed Preparative Column
    Brochures
    The Kinetex 2.6 µm Application Notebook
    Poster
    Exploring LC Selectivity Using Steroids Infographic
    Technical Notes
    Demystifying L/dp Ratio When Working with Allowable Adjustments
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    FAQs

    There are many potential sources and solutions: Put caps with filters or sorbent traps on your HPLC mobile phase bottles and solvent waste receptacles; don’t leave residual acetonitrile in pipette barrels; do all your potency extractions and standard preparations in a fume hood; and if you are using a triple quad MS for pesticide analysis, don’t discharge the vacuum exhaust from the ionization source into the lab.
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