For security purposes
FOR SECURITY PURPOSES - because Internet Explorer is no longer supported by Microsoft, we suggest that you interact with our secure site through one of our supported browsers - Google Chrome, Firefox, or MS Edge. If you continue to use this website with Internet Explorer you do so at your own risk and you may encounter problems.
Product Information
Phase Detail
Strata-X-A SPE Products
Strata-X-A solid phase extraction (SPE) sorbent is a polymeric strong anion exchange sorbent that can be used to cleanup acidic compounds

Strata-X-A SPE Products

Strong Anion Mixed-Mode Solid Phase Extraction (SPE)

A strong anion-exchange functionalized polymeric sorbent that allows for complete retention of weakly acidic compounds with a pKa greater than 2, making 100% organic wash conditions possible. A 100% organic wash ensures that the maximum amount of interferences are removed from the target compound.

Brand
Strata-X
Recommended Use
Extraction of basic drugs from biological samples

3 Mechanism of Retention

Strong Anion-Exchange


Ï€-Ï€ Bonding


Hydrophobic Interaction


Available Formats

96-Well Plates
Microelution 96-Well Plates
1, 3, and 6 mL Tubes
Gigaâ„¢ Tubes (12-150 mL Tubes)

Starting Method

For Acids with pKa > 2

Column:
1 mL Methanol
Equilibrate:
1 mL Water, pH 6-7
Load:
Diluted Sample pH 6-7
Wash 1:
1 mL 25 mM Ammonium Acetate Buffered, pH 6-7
Wash 2:
1 mL Methanol (collect this fraction to analyze Neutral/Bases)
Elute Acid:
2x 500 µL 5 % Formic Acid in Methanol

Based on 30 mg/1 mL sorbent mass. The above is a convenient starting point for SPE method development, further optimization may be required to tailor the method for your specific extraction needs.