Strata-XL-A SPE Products

Large Particle Strong Anion Mixed-Mode Solid Phase Extraction (SPE)

A large particle, strong anion-exchange functionalized polymeric sorbent that allows for complete retention of acidc compounds with a pK_a greater than 2, making 100% organic wash conditions possible. A 100% organic wash ensures that the maximum amount of interferences are removed from the target compound. The large particle format makes this sorbent ideal for processing large volumes or viscous samples.

Brand Strata-X
Recommended Use Extraction of weakly acidic compounds present in viscous samples

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3 Mechanism of Retention

Strong Anion-Exchange

π-π Bonding

Hydrophobic Interaction

Available Formats

96-Well Plates

1, 3, and 6 mL Tubes

Giga™ Tubes (12-150 mL Tubes)

Starting Method

For Acids with pK_a > 2

Column: 1 mL Methanol
Equilibrate: 1 mL Water, pH 6-7
Load: Diluted Sample pH 6-7
Wash 1: 1 mL 25 mM Ammonium Acetate Buffered, pH 6-7
Wash 2: 1 mL Methanol (collect this fraction to analyze Neutral/Bases)
Elute Acids: 2x 500 µL 5 % Formic Acid in Methanol

Based on 30 mg/1 mL sorbent mass. The above is a convenient starting point for SPE method development, further optimization may be required to tailor the method for your specific extraction needs.