Identification and Quantification of Designer Drugs in Urine by LC-MS/MS

Novel compounds that, while they may be similar in structure to current drugs of abuse, can pose analytical challenges as unknown structural differences can affect how they perform under LC-MS/MS analysis. As the number of new designer drugs rises, methods which can be easily expanded and have a non-selective sample preparation procedure are needed. This method uses a simple dilute and shoot sample preparation followed by LC-MS/MS using a Kinetex 2.6 µm C18 LC column and a SCIEX QTRAP 4500 MS/MS system.