Clarity SPE
15 Minute Clean Up from Biological Samples
Clarity OTX—and its newest iteration, Clarity OTX PRO—isolate RNA- and DNA-based therapeutics/metabolites from biological fluids and tissues in less time using mixed-mode solid phase extraction (SPE) and optimized buffer products.
- No liquid–liquid extraction (LLE) required
- 80% typical extraction recoveries
- Optimized for LC-MS bioanalysis
Oligonucleotide Purification Products
Clarity OTX™ SPE
Prior to LC-MS analysis, therapeutic oligonucleotides must be isolated from interferences such as salts, sugars, large proteins, and genomic DNA. Using a mixed-mode solid phase extraction (SPE) sorbent in conjunction with carefully formulated buffers, Clarity OTX consistently delivers high recoveries.
Material Characteristics
| Clarity Products | Particle Support | Bonded Phase | Particle Shape/Size (μm) | Pore Size(Å) | Surface Area (m2/g) |
|---|---|---|---|---|---|
Polymer (surface modified PSDVB) |
Mixed-mode anion exchanger |
33 |
85 |
800 |
|
Polymer (PSDVB) |
Hydrophilic polymer coating |
35 |
500 |
300 |
|
Silica |
C18 |
55 |
140 |
300 |
Clarity OTX and Clarity QSP are patented by Phenomenex. U.S. Patent No. 7,119,145
Clarity BioSolutions Product Selection
Purification
Characterization / Analysis
