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Product Information
Phase Detail
Kinetex Core-Shell C18 HPLC Column
C18 HPLC Column - Kinetex core-shell C18 columns offer increased efficiencies over traditionally porous C18 LC columns on HPLC/UHPLC systems

Kinetex Core-Shell C18 HPLC Column

The Go-To Core-Shell Selectivity for Hydrophobic Compounds!

The well-rounded, all-purpose core-shell Kinetex C18 HPLC column produces increased efficiencies over traditional, fully porous columns. Yielding remarkable chromatographic resolution, higher peak capacities, and greater sensitivity, so labs can get the most out of every HPLC or UHPLC analysis.

  • Compatible with all Analytical HPLC/UHPLC Systems*
  • Four fully scalable particle sizes available
  • Excellent Reproducibility and Batch-to-Batch Confidence
  • USP: L1

*Kinetex C18 analytical columns are compatible with all LC system with standard LC column end-fittings threaded in 10-32. Please contact us for any questions and information about fitting compatibility and any other column internal diameters.

Carbon Load
10.0, 12 (effective)
Surface Area (m²/g)
Particle Size
1.3, 1.7, 2.6, 5
Recommended Use
All-purpose hydrophobic retention and methylene selectivity

Balances Retention and Performance 

Balanced C18 phase that provides the highest degree of hydrophobic selectivity relative to the other Kinetex phases.

Balances Retention and Performance Graph


Upgrade from Traditional Fully Porous to Kinetex Core-Shell

Instantly get more out of your analytical method and upgrade to the Kinetex C18. Take advantage of the fully scalable available particle sizes of Kinetex C18 to bring improved performance to any LC system!

1.7 µm Fully Porous vs. 1.7 µm Core-Shell

Conditions for both columns:

Kinetex 1.7 µm C18
Traditional 1.7 µm C18
50 x 2.1 mm
Mobile Phase:
Acetonitrile / Water (50:50)
Flow Rate:
0.6 mL/min
25 °C
UV @ 254 nm
1. Acetophenone
2. Benzene
3. Toluene
4. Naphthalene

Fully Porous vs. Core-Shell

Application ID 18578 and Application ID 18586
◊ Signal-to-noise ratio of peak 2; ∆ Based on average peak widths; *Waters, ACQUITY, and UPLC are registered trademarks of Waters Corporation. Phenomenex is not affiliated with Waters Corporation. Comparative separations may not be representative of all applications. Conditions same for both columns except where noted.
Conditions for both columns:

Kinetex 2.6 µm C18 100 Å    
Traditional 5 µm ODS-3 100 Å
Kinetex: 150 x 4.6 mm
Traditional: 250 x 4.6 mm
Mobile Phase:
A: 0.1 % Phosphoric acid in  Water
B: 0.1 % Phosphoric acid in Acetonitrile
5 % to 95 % B in 9 min (150 x 4.6 mm)
5 % to 95 % B in 15 min (250 x 4.6 mm)
Flow Rate:
1.8 mL/min
50 °C
UV @ 215 nm (22 °C)
1. Procainamide
2. Acetaminophen
3. Folic acid
4. Sulfathiazole
5. Acebutolol
6. Dextromethorphan
7. Diphenhydramine
8. Propafenone
9. Amitriptyline
10. Fluoxetine
11. Naproxen
12. Diflunisal
13. Indomethacin

Performance with Kinetex C18 on HPLC and UHPLC Systems

Quickly improve the productivity and performance of your existing methods and utilize the core shell advantage to deliver performance you need at backpressures the system can handle.

Fully Porous vs. Core-Shell

Application ID 20763, 20764, 20765
*Agilent 1100 was optimized with the Core-Shell Performance Enhancement Kit AQ0-8892. Agilent and ZORBAX are registered trademarks of Agilent Technologies, Inc. Phenomenex is not affiliated with Agilent Technologies. Comparative separations may not be representative of all applications.

Kinetex 2.6 µm C18 (Agilent 1100*)
Kinetex 2.6 µm C18 (Agilent 1290)
ZORBAX 1.8 µm SB-C18 (Agilent 1290)
100 x 4.6 mm
Mobile Phase:
A: Water with 0.1% TFA
B: Acetonitrile with 0.1% TFA
Time (min)
% B
Flow Rate:
1.2 mL/min
UV @ 210 nm
Mupirocin degradants