β-Glucuronidase removal is the process of eliminating the large β-Glucuronidase protein from a sample after hydrolysis to ensure a better analysis. Often labs perform dilute-and-shoot but the β-Glucuronidase can interfere with analyte recovery, such as reduced sensitivity and high signal-to-noise. Dilute-and-shoot is a popular method to reduce the concentration of Beta-glucuronidase, but it also lowers the analyte concentration, potentially impacting the sensitivity..
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