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Analysis of Antibody Drug Conjugates (ADCs) using High Efficiency Gel Filtration Columns (TN-1176)
Gel filtration chromatography is a common method used for the analysis of macromolecules, including antibody drug conjugates (ADCs). This presents unique challenges since ADCs are more hydrophobic than their parent monoclonal antibodies mAbs). In this study, we investigate the feasibility of using a non-toxic ADC model with a Yarra 3 µm SEC-3000 column for aggregate analysis.
Analysis of Antibody Drug Conjugates (ADCs) using High Efficiency Gel Filtration Columns (TN-1176)
Gel filtration chromatography is a common method used for the analysis of macromolecules, including antibody drug conjugates (ADCs). This presents unique challenges since ADCs are more hydrophobic than their parent monoclonal antibodies mAbs). In this study, we investigate the feasibility of using a non-toxic ADC model with a Yarra 3 µm SEC-3000 column for aggregate analysis.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Size Exclusion
Analysis of Antibody Drug Conjugates (ADCs) using High Efficiency Gel Filtration Columns (TN-1176)
Gel filtration chromatography is a common method used for the analysis of macromolecules, including antibody drug conjugates (ADCs). This presents unique challenges since ADCs are more hydrophobic than their parent monoclonal antibodies mAbs). In this study, we investigate the feasibility of using a non-toxic ADC model with a Yarra 3 µm SEC-3000 column for aggregate analysis.
| Target Industries: | Biopharmaceutical Analysis, Pharmaceutical |
| Techniques: | HPLC, Gel Filtration Chromatography (GFC) |
| Brands: | Yarra |
| Separation Modes: | Size Exclusion |
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.