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Chromatography Tips: March Edition

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Chromatography Tips: March Edition
This month's chromatography tips go over LC system optimisation, sample tip recoveries, and GC column dimensions. Access them here!

Posted on Mar 31, 2025

Get ready to level up your chromatography skills with our Chromatography Tips Digital Library! Every month, we’ll release fresh content featuring expert tips on LCGC, and Sample Prep—all categorized by FundamentalApplication, and Troubleshooting themes, plus difficulty levels to suit every expertise!

Check out this month’s exciting new tips:

LC System Optimisation for UHPLC Performance on any HPLC
HPLC/UHPLC Tip
Level: Basic
Learn how to fine-tune your HPLC method, minimize system volume, and adjust detector settings to achieve sharper peaks and better separations. 

Why are my recoveries greater than 100%?
Sample Prep Tip
Level: Intermediate
When performing analyte extraction with SPE, we expect 100% recovery. If recovery is lower, this would suggest there is an issue with retrieval of the analyte from the sorbent but what are some of the reasons you may see a recovery greater than what you were expecting (or over 100%)?

GC Video Tip: GC Column Dimensions
This video answers the common question: “What dimension of column do I need for my GC method?” Watch the full video here.

Access all the tips here in our FREE library!

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