Sample Preparation
Samples are often not homogeneous, contain particulates and/or levels of interfering compounds that make analysis difficult, or possibly damage the chromatography system/column. This is often due to the matrix of the sample. The term matrix refers to the surrounding media that contains the analytes and/or contaminants. Some examples of matrices are water (aqueous), urine, soil, plasma or blood. Samples like these are common across a diverse group of industries including: pharmaceutical, clinical, toxicology, environmental testing, agriculture and food and beverage.
Sample preparation is a technique that is used to remove contaminants from a sample and improve chromatographic performance and sample detection. In certain circumstances sample preparation can be used to increase the concentration of analytes.
| Method | Description |
|---|---|
| Solid Phase Extraction (SPE) | Clean-up and concentration of target analytes from blood, urine, plasma, food, and environmental sample matrices |
| Protein Precipitation (PPT) | Rapid removal of proteins from plasma |
| Phospholipid Removal (PLR) | Rapid removal of proteins and phospholipids from biological samples |
| Filtration | Removal of particulates from various samples |
| QuEChERS | An acronym for Quick, Easy, Cheap, Effective, Rugged, and Safe used for multi-residue analysis |
| Supported Liquid Extraction (SLE) | High efficiency solid support used to mimic liquid-liquid extractions |
| β-Glucuronidase Removal | In-well hydrolysis capabilities and rapid removal of β-Glucuronidase from urine samples |
| Magnetic Beads | Used for effective protein and peptide isolation |
