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Automated Sample Preparation for a Comprehensive Drug Research Panel from Oral Fluid Using Quantisal Device
There is a growing interest in oral fluid testing over other test matrices such as urine and blood because it is non-intrusive, convenient, and observable – making adulteration or substitution difficult. In our previous technical note (www.phenomenex.com/ TN100) we developed a unique sample preparation procedure that encompasses a wide range of illicit and pain management drugs that result in a very clean extract with high recovery.1,2 Here, we extend our scope in automating the procedure by utilizing a liquid handler. The speed of data analysis has improved significantly in the past decade due to increased detection capabilities of mass spectrometry coupled with liquid chromatography. Despite these advances, the biggest time constraint in sample processing is the manual process around sample preparation. One survey attributes 61% of an analytical chemist’s time is spent on sample processing3. Automated liquid handling can increase lab productivity and circumvents human error.

Automated Sample Preparation for a Comprehensive Drug Research Panel from Oral Fluid Using Quantisal Device

There is a growing interest in oral fluid testing over other test matrices such as urine and blood because it is non-intrusive, convenient, and observable – making adulteration or substitution difficult. In our previous technical note (www.phenomenex.com/ TN100) we developed a unique sample preparation procedure that encompasses a wide range of illicit and pain management drugs that result in a very clean extract with high recovery.1,2 Here, we extend our scope in automating the procedure by utilizing a liquid handler. The speed of data analysis has improved significantly in the past decade due to increased detection capabilities of mass spectrometry coupled with liquid chromatography. Despite these advances, the biggest time constraint in sample processing is the manual process around sample preparation. One survey attributes 61% of an analytical chemist’s time is spent on sample processing3. Automated liquid handling can increase lab productivity and circumvents human error.
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