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LC-MS/MS N-Nitroso Rasagiline Analysis using a SCIEX 5500+
This study demonstrates that the combination of Kinetex™ Biphenyl chromatography and a SCIEX 5500+ mass spectrometer enables reliable quantification of N-Nitroso Rasagiline at a specification level of 1.8 ng/mL. The method exhibited excellent precision, with a relative standard deviation (RSD) of 1.02% at the specification level and 3.21% at the limit of quantitation (0.09 ng/mL). These results confirm the method’s suitability for trace-level analysis of N-nitroso impurities in drug products, offering both sensitivity and reproducibility.
LC-MS/MS N-Nitroso Rasagiline Analysis using a SCIEX 5500+
This study demonstrates that the combination of Kinetex™ Biphenyl chromatography and a SCIEX 5500+ mass spectrometer enables reliable quantification of N-Nitroso Rasagiline at a specification level of 1.8 ng/mL. The method exhibited excellent precision, with a relative standard deviation (RSD) of 1.02% at the specification level and 3.21% at the limit of quantitation (0.09 ng/mL). These results confirm the method’s suitability for trace-level analysis of N-nitroso impurities in drug products, offering both sensitivity and reproducibility.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Reversed Phase
Phases:
LC-MS/MS N-Nitroso Rasagiline Analysis using a SCIEX 5500+
This study demonstrates that the combination of Kinetex™ Biphenyl chromatography and a SCIEX 5500+ mass spectrometer enables reliable quantification of N-Nitroso Rasagiline at a specification level of 1.8 ng/mL. The method exhibited excellent precision, with a relative standard deviation (RSD) of 1.02% at the specification level and 3.21% at the limit of quantitation (0.09 ng/mL). These results confirm the method’s suitability for trace-level analysis of N-nitroso impurities in drug products, offering both sensitivity and reproducibility.
| Target Industries: | Pharmaceutical |
| Techniques: | HPLC Reversed Phase |
| Brands: | Kinetex |
| Separation Modes: | Reversed Phase |
| Phases: | Kinetex Biphenyl |
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.
Phenomenex is a technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers worldwide.