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Advancements in PFAS Extraction Methods from Blood and Serum

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Comparing PFAS Extraction Methods from Blood and Serum
Explore effective PFAS extraction methods for blood and serum, highlighting protein precipitation as the top technique for analyzing 34 PFAS analytes.

Posted on Feb 7, 2025

Recent research has identified a link between. This has led to increased efforts to understand and measure PFAS levels and their potential impact on human health. There is now a pressing need for effective biomonitoring of PFAS. As a result, there is an urgent need for effective methods to monitor and analyze PFAS levels in biological samples to better understand their distribution, bioaccumulation, and potential health effects. The current CDC procedure, which measures 17 PFAS analytes in serum, has been expanded to include 34 analytes to better assess exposure from sources like contaminated food, packaging, drinking water, and various consumer products.

A recent article published by LCGC International presents a comparative study of various sample preparation methods for the most effective PFAS extraction from blood and serum samples. The study found that average percent recoveries from protein precipitation were superior to those from the WAX SPE method, indicating that a simple protein precipitation approach is more effective for the diverse panel of 34 PFAS. Read the full article here

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