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Analysis of IdeS Digested Monoclonal Antibody Fragments
IdeS, a cysteine protease, is used for partial digestion of mAbs and generates a (Fab’)2 fragment and two Fc fragments (Fc/2) to allow for better characterization of the Fc fragment using a Biozen 2.6 µm WidePore C4 LC column.
Analysis of IdeS Digested Monoclonal Antibody Fragments
IdeS, a cysteine protease, is used for partial digestion of mAbs and generates a (Fab’)2 fragment and two Fc fragments (Fc/2) to allow for better characterization of the Fc fragment using a Biozen 2.6 µm WidePore C4 LC column.
Document Type:
Technical Notes
Target Industries:
Techniques:
Brands:
Separation Modes:
Reversed Phase
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